Department of Ultrasound Medicine, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan 442008, Hubei, China.
Comput Math Methods Med. 2022 Feb 4;2022:2102496. doi: 10.1155/2022/2102496. eCollection 2022.
To investigate the significance of echocardiography combined with N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels in the evaluation and prognosis of diastolic heart failure (DHF).
Clinical data were collected from 168 patients with DHF. Serum levels of NT-pro BNP were first measured by ELISA. Meanwhile, the echocardiography was used to examine left ventricular end-diastolic diameter (LVEDD), left ventricular diameter (LVD), and other parameters. Multivariate logistic regression analysis was performed for variables in heart failure assessment grade or poor prognosis. Finally, the predictive ability for New York Heart Association (NYHA) class as well as prognosis was assessed by ROC curves.
NT-pro BNP was the overexpression in the serum of patients with DHF. And the degree of elevation was related to NYHA class, while NT-pro BNP levels were significantly higher in the P-MACE group than in the N-MACE group. According to the multivariate logistic regression analysis, the ratio of peak velocity of left atrial early diastolic blood flow to early diastolic peak velocity of mitral annulus (/Ea) and serum NT-pro BNP level was risk factors for NYHA class and prognosis. However, LVEF, LVEDD, and flow propagation velocity (Vp) can be a benefit condition. In addition, ROC curve showed that echocardiography combined with NT-pro BNP content had higher accuracy in NYHA class and prognostic assessment of DHF than applied separately.
The diagnosis of echocardiography combined with NT-pro BNP levels has the potential to distinguish the NYHA class in heart function of patients with DHF and determine the prognosis of patients.
探讨超声心动图联合氨基末端脑钠肽前体（NT-proBNP）水平在舒张性心力衰竭（DHF）评估和预后中的意义。
收集 168 例 DHF 患者的临床资料，采用 ELISA 法检测血清 NT-proBNP 水平，同时行超声心动图检查左心室舒张末期内径（LVEDD）、左心室直径（LVD）等参数，对心力衰竭评估分级或预后不良的变量进行多因素 logistic 回归分析，最后采用 ROC 曲线评估对纽约心脏病协会（NYHA）分级及预后的预测能力。
DHF 患者血清中 NT-proBNP 呈过度表达，且升高程度与 NYHA 分级相关，P-MACE 组 NT-proBNP 水平明显高于 N-MACE 组。多因素 logistic 回归分析显示，左心房早期舒张血流峰值速度与二尖瓣环早期舒张峰值速度的比值（/Ea）和血清 NT-proBNP 水平是 NYHA 分级和预后的危险因素，而 LVEF、LVEDD 和血流传播速度（Vp）则是获益条件。此外，ROC 曲线显示，超声心动图联合 NT-proBNP 含量对 DHF 患者心功能 NYHA 分级和预后评估的准确性高于单独应用。
超声心动图联合 NT-proBNP 水平有助于区分 DHF 患者心功能的 NYHA 分级，判断患者预后。
