超声心动图联合血清 C 反应蛋白水平对慢性心力衰竭的诊断价值。
Diagnostic value of echocardiography combined with serum C-reactive protein level in chronic heart failure.
机构信息
Cardiovascular Medicine Department, The Third Affiliated Hospital of Guangzhou Medical University, No.63 Duobao Road, Liwan District, Guangzhou, 510150, Guangdong Province, China.
出版信息
J Cardiothorac Surg. 2023 Mar 25;18(1):94. doi: 10.1186/s13019-023-02176-7.
BACKGROUND
Chronic heart failure (CHF) is regarded as common clinical heart disease. This study aims to investigate the clinical diagnostic value of echocardiography (Echo) and serum C-reactive protein (CRP) levels in patients with CHF.
METHODS
A total of 75 patients with CHF (42 males, 33 females, age 62.72 ± 1.06 years) were enrolled as study subjects, with 70 non-CHF subjects (38 males, 32 females, age 62.44 ± 1.28 years) as controls. The left ventricular ejection fraction (LVEF), fraction shortening rate of the left ventricle (FS), and early to late diastolic filling (E/A) were determined by Echo, followed by an examination of the expression of serum CRP by ELISA. In addition, the Pearson method was used to analyze the correlation between echocardiographic quantitative parameters (EQPs) (LVEF, FS, and E/A) and serum CRP levels. Receiver operating characteristic (ROC) curve was adopted to evaluate the diagnostic efficacy of EQPs and serum CRP levels for CHF. The independent risk factors for CHF patients were measured by logistics regression analysis.
RESULTS
The serum CRP level of CHF patients was elevated, the values of LVEF and FS decreased, and the E/A values increased. ROC curve revealed that the EQPs (LVEF, FS, and E/A) combined with serum CRP had high diagnostic values for CHF patients. Logistic regression analysis showed that the EQPs (LVEF, FS, and E/A) and serum CRP levels were independent risk factors for CHF patients.
CONCLUSION
Echo combined with serum CRP level has high clinical diagnostic values for CHF patients.
背景
慢性心力衰竭（CHF）被认为是常见的临床心脏病。本研究旨在探讨超声心动图（Echo）和血清 C 反应蛋白（CRP）水平对 CHF 患者的临床诊断价值。
方法
共纳入 75 例 CHF 患者（男 42 例，女 33 例，年龄 62.72±1.06 岁）作为研究对象，另选取 70 例非 CHF 患者（男 38 例，女 32 例，年龄 62.44±1.28 岁）作为对照组。通过 Echo 检测左心室射血分数（LVEF）、左心室缩短分数（FS）和舒张早期晚期充盈（E/A），采用 ELISA 法检测血清 CRP 表达水平。采用 Pearson 方法分析超声心动图定量参数（LVEF、FS 和 E/A）与血清 CRP 水平的相关性。采用受试者工作特征（ROC）曲线评价 EQPs 和血清 CRP 水平对 CHF 的诊断效能。采用 Logistic 回归分析评估 CHF 患者的独立危险因素。
结果
CHF 患者血清 CRP 水平升高，LVEF 和 FS 值降低，E/A 值升高。ROC 曲线显示，EQPs（LVEF、FS 和 E/A）联合血清 CRP 对 CHF 患者具有较高的诊断价值。Logistic 回归分析显示，EQPs（LVEF、FS 和 E/A）和血清 CRP 水平是 CHF 患者的独立危险因素。
结论
Echo 联合血清 CRP 水平对 CHF 患者具有较高的临床诊断价值。
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