Peters L J, Brock W A, Johnson T, Meyn R E, Tofilon P J, Milas L
Int J Radiat Oncol Biol Phys. 1986 Apr;12(4):459-67. doi: 10.1016/0360-3016(86)90053-2.
Several predictors of tumor radiocurability are already integrated into clinical practice, for example, tumor size, gross morphology (that is, infiltrative or exophytic), histologic type and grade. These are nonspecific and relatively imprecise. The aim of research into predictive assays is not only to refine the discrimination of existing predictors, but also to suggest specific experimental approaches for overcoming tumor radioresistance in individual patients. Two broad categories of predictive assays can be defined: direct and indirect measurement of tumor cell survival and/or repair capability following irradiation, and measurement of cellular and extracellular parameters affecting radiosensitivity. The ongoing research at The University of Texas M. D. Anderson Hospital is overviewed to illustrate potential methods for predicting radiocurability.
肿瘤放射可治愈性的几个预测指标已被纳入临床实践，例如肿瘤大小、大体形态（即浸润性或外生性）、组织学类型和分级。这些指标是非特异性的，且相对不精确。预测分析研究的目的不仅是优化现有预测指标的辨别能力，还在于提出针对个体患者克服肿瘤放射抗性的具体实验方法。可以定义两大类预测分析：直接和间接测量照射后肿瘤细胞的存活和/或修复能力，以及测量影响放射敏感性的细胞和细胞外参数。本文概述了得克萨斯大学MD安德森癌症中心正在进行的研究，以阐明预测放射可治愈性的潜在方法。
