Mosime Lesedi B, Newton-Foot Mae, Nel Pieter
Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Department of Medical Microbiology, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.
S Afr J Infect Dis. 2022 Jan 19;37(1):321. doi: 10.4102/sajid.v37i1.321. eCollection 2022.
Oral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown. This study investigated the prevalence and mechanisms of fosfomycin resistance amongst urinary pathogens in the Western Cape, South Africa. Of the 200 isolates collected during the study period (2019-2020), seven (3.5%) were fosfomycin resistant. Mutations in the and transporter genes were the most common mechanism of resistance detected. These findings support the ongoing use of fosfomycin as an empiric antibiotic choice for the treatment of community-acquired UTI in this setting.
口服磷霉素常用于治疗非复杂性尿路感染（UTI），虽然南非许多医疗机构都报告了对其的耐药性，但目前的流行情况仍不清楚。本研究调查了南非西开普省尿路病原体中磷霉素耐药性的流行情况及其机制。在研究期间（2019 - 2020年）收集的200株分离株中，有7株（3.5%）对磷霉素耐药。检测到的最常见耐药机制是 和 转运蛋白基因突变。这些发现支持在此环境下继续将磷霉素用作治疗社区获得性UTI的经验性抗生素选择。
