Thomas A H
J Antimicrob Chemother. 1986 Mar;17(3):269-79. doi: 10.1093/jac/17.3.269.
The polyene antibiotics and the N-substituted imidazoles (azoles) are two groups of clinically important antifungal drugs. Both are hydrophobic and both interact with the plasma membrane of susceptible fungi but the mode of action of the two groups is not fully resolved. In this paper their biological properties are reviewed in the context of recent work so that common features may be identified and further areas of research indicated.
多烯类抗生素和N-取代咪唑类（唑类）是两组临床上重要的抗真菌药物。两者均具有疏水性，且都与易感真菌的质膜相互作用，但这两组药物的作用方式尚未完全明确。本文结合近期研究工作对它们的生物学特性进行综述，以便找出共同特征并指出进一步的研究领域。
