酮康唑对两性霉素B抗白色念珠菌杀菌作用的影响。
Effect of ketoconazole on the fungicidal action of amphotericin B in Candida albicans.
作者信息
Sud I J, Feingold D S
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):185-7. doi: 10.1128/AAC.23.1.185.
Abstract
Amphotericin B-susceptible Candida albicans became resistant to the drug after growth in the presence of ketoconazole. Chromatographic analysis of cellular sterols showed that the organisms became depleted of ergosterol in parallel with the development of amphotericin B resistance. The implications of these findings are discussed in relation to combination chemotherapy with these two important antifungal agents.
摘要
对两性霉素B敏感的白色念珠菌在酮康唑存在的情况下生长后对该药物产生了耐药性。细胞甾醇的色谱分析表明，随着两性霉素B耐药性的发展，这些生物体中的麦角甾醇逐渐减少。结合这两种重要抗真菌药物的联合化疗对这些发现的意义进行了讨论。
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