唑类药物的生物依赖性杀菌活性。
Organism-dependent fungicidal activities of azoles.
作者信息
Manavathu E K, Cutright J L, Chandrasekar P H
机构信息
Division of Infectious Diseases, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
出版信息
Antimicrob Agents Chemother. 1998 Nov;42(11):3018-21. doi: 10.1128/AAC.42.11.3018.
Abstract
We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 microg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration dependent. In contrast, no killing of Candida albicans occurred in the presence of itraconazole and voriconazole at concentrations as high as 10 microg/ml, although candidal growth was inhibited compared to the drug-free control. Amphotericin B (1.25 to 10 microg/ml), on the other hand, killed both A. fumigatus and C. albicans. Similar results were obtained for non-A. fumigatus aspergilli and non-C. albicans Candida species. These observations indicate that both itraconazole and voriconazole are cytocidal agents for Aspergillus species but not for Candida species, suggesting that azoles possess organism-dependent fungicidal activities.
摘要
我们通过时间杀菌研究调查了伊曲康唑和伏立康唑对曲霉菌种的抗真菌活性，并将结果与白色念珠菌种的结果进行了比较。烟曲霉分生孢子暴露于不同浓度（1.25至10微克/毫升）的伊曲康唑和伏立康唑会导致细胞死亡；杀细胞作用具有时间和浓度依赖性。相比之下，在浓度高达10微克/毫升的伊曲康唑和伏立康唑存在下，白色念珠菌没有被杀灭，尽管与无药对照相比念珠菌生长受到抑制。另一方面，两性霉素B（1.25至10微克/毫升）可杀死烟曲霉和白色念珠菌。对于非烟曲霉曲霉菌种和非白色念珠菌念珠菌种也获得了类似结果。这些观察结果表明，伊曲康唑和伏立康唑都是针对曲霉菌种的杀细胞剂，但不是针对白色念珠菌种的，这表明唑类具有依赖于生物体的杀菌活性。
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