Medical Department, Northwest Minzu University, Lanzhou, Gansu, 730000, China.
Key Laboratory of Environmental Ecology and Population Health in Northwest Minority Areas, Northwest Minzu University, Lanzhou, Gansu, 730000, China.
Epigenomics. 2022 Apr;14(7):405-421. doi: 10.2217/epi-2021-0190. Epub 2022 Feb 16.
Psychological stress can increase the risk of a wide range of negative health outcomes. Studies have been completed to determine if DNA methylation changes occur in the human brain because of stress and are associated with long-term effects and disease, but results have been inconsistent. Human candidate gene studies (150) and epigenome-wide association studies (67) were systematically evaluated to assess how DNA methylation is impacted by stress during the prenatal period, early childhood and adulthood. The association between DNA methylation of exon 1F and child maltreatment and early life adversity was well demonstrated, but other genes did not exhibit a clear association. The reproducibility of individual CpG sites in epigenome-wide association studies was also poor. However, biological pathways, including stress response, brain development and immunity, have been consistently identified across different stressors throughout the life span. Future studies would benefit from the increased sample size, longitudinal design, standardized methodology, optimal quality control, and improved statistical procedures.
心理压力会增加多种负面健康结果的风险。已经有研究致力于确定人类大脑中是否会因为压力而发生 DNA 甲基化改变，以及这些改变是否与长期效应和疾病有关，但结果并不一致。本研究系统地评估了人类候选基因研究（150 项）和全基因组甲基化关联研究（67 项），以评估在产前、儿童早期和成年期期间压力对 DNA 甲基化的影响。exon 1F 的 DNA 甲基化与儿童期虐待和生命早期逆境之间的关联得到了很好的证明，但其他基因则没有表现出明显的关联。全基因组甲基化关联研究中单个 CpG 位点的重现性也很差。然而，在整个生命周期中，不同应激源下的应激反应、大脑发育和免疫等生物学途径都得到了一致的鉴定。未来的研究将受益于增加的样本量、纵向设计、标准化方法、最佳质量控制和改进的统计程序。
