School of Chemistry and Chemical Engineering, School of Life Science, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, 312000, Zhejiang, P. R. China.
School of Chemistry and Chemical Engineering, Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, Zhejiang, P. R. China.
Org Biomol Chem. 2022 Mar 2;20(9):1952-1957. doi: 10.1039/d1ob02479e.
A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl·2HO/TBHP and produced the desired β-acylated enaminones in a ()-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C-C and C-N bonds were formed a one-pot strategy including the process of radical addition and recombination.
发展了一种简便高效的烯基叠氮化物与醛的氧化官能化方法，可得到各种β-酰化烯胺酮。该交叉偶联反应在 CuCl·2HO/TBHP 的存在下进行，以 ()-立体选择性和原子经济性的方式得到了所需的β-酰化烯胺酮，这使得该方法特别有吸引力。在转化过程中，新的 C-C 和 C-N 键通过包括自由基加成和重组过程的一锅法形成。
