Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, No.1, Shuaifuyuan, Dongcheng District, Beijing 100730, China.
Acta Derm Venereol. 2022 Mar 28;102:adv00684. doi: 10.2340/actadv.v102.1985.
Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment.
弹性纤维溶解性巨细胞肉芽肿，一种特发性肉芽肿性皮肤病，其特征是在暴露于阳光的区域出现环状斑块，也被称为光化性肉芽肿或环状弹性纤维溶解性巨细胞肉芽肿。已经报道了许多非典型的临床表现和涉及避光区域的病变。本回顾性研究对 105 例患者进行了研究，目的是总结该疾病患者的临床和组织学特征；为弹性纤维溶解性巨细胞肉芽肿是一个更好的术语的观点提供证据，该术语包含了所有临床上具有弹性溶解、弹性吞噬作用和组织学多核巨细胞浸润的形态类型；并建立了一种新的临床分类。不同的临床表现进一步分为环状、丘疹状、巨大型、混合和全身性。病理表现分为巨细胞、坏死性、组织细胞性、类肉瘤和混合性。糖尿病或糖耐量受损是最常见的合并症。口服小剂量皮质类固醇可能是一种有效的治疗方法。
