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Cladobotric 酸：来自 sp. 的培养物、半合成类似物和抗菌活性的代谢产物。

Cladobotric Acids: Metabolites from Cultures of sp., Semisynthetic Analogues and Antibacterial Activity.

机构信息

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, U.K.

School of Biological Sciences, Life Sciences Building, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, U.K.

出版信息

J Nat Prod. 2022 Mar 25;85(3):572-580. doi: 10.1021/acs.jnatprod.1c01063. Epub 2022 Feb 16.

DOI:10.1021/acs.jnatprod.1c01063
PMID:35170975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9097583/
Abstract

Three new polyketide-derived natural products, cladobotric acids G-I (-), and six known metabolites (, , -) were isolated from fermentation of the fungus sp. grown on rice. Their structures were elucidated by extensive spectroscopic methods. Two metabolites, cladobotric acid A () and pyrenulic acid A (), were converted to a series of new products (-) by semisynthesis. The antibacterial activities of all these compounds were investigated against the Gram-positive pathogen including methicillin-susceptible (MSSA), methicillin-resistant and vancomycin-intermediate (MRSA/VISA), and heterogeneous vancomycin-intermediate (hVISA) strains. Results of these antibacterial assays revealed structural features of the unsaturated decalins important for biological activity.

摘要

从真菌 sp. 在大米上的发酵产物中分离得到了三个新的聚酮衍生天然产物 cladobotric 酸 G-I（-）和六个已知代谢产物（， ，-）。通过广泛的光谱方法阐明了它们的结构。两种代谢产物 cladobotric 酸 A () 和 pyrenulic 酸 A () 通过半合成转化为一系列新产物 (-)。所有这些化合物的抗菌活性都针对革兰氏阳性病原体 进行了测试，包括耐甲氧西林的金黄色葡萄球菌（MSSA）、耐甲氧西林和万古霉素中间型（MRSA/VISA）以及异质性万古霉素中间型（hVISA）菌株。这些抗菌试验的结果揭示了不饱和十氢化萘的结构特征对生物活性很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/a064ee75ee26/np1c01063_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/c918fd424468/np1c01063_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/092bf77c6580/np1c01063_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/4f1382e8223f/np1c01063_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/a064ee75ee26/np1c01063_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/c918fd424468/np1c01063_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/092bf77c6580/np1c01063_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/4f1382e8223f/np1c01063_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/577d/9097583/a064ee75ee26/np1c01063_0004.jpg

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本文引用的文献

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Org Biomol Chem. 2021 Nov 10;19(43):9506-9513. doi: 10.1039/d1ob01766g.
2
Functional Analysis of the Fusarielin Biosynthetic Gene Cluster.镰孢菌素生物合成基因簇的功能分析
Molecules. 2016 Dec 13;21(12):1710. doi: 10.3390/molecules21121710.
3
Natural products from filamentous fungi and production by heterologous expression.丝状真菌的天然产物及其异源表达生产
基于形态学、分子和代谢组学数据的真菌寄生属多相系统学
J Fungi (Basel). 2022 Aug 20;8(8):877. doi: 10.3390/jof8080877.
Appl Microbiol Biotechnol. 2017 Jan;101(2):493-500. doi: 10.1007/s00253-016-8034-2. Epub 2016 Dec 13.
4
Draft Genome Sequence of Methicillin-Sensitive Staphylococcus aureus ATCC 29213.甲氧西林敏感金黄色葡萄球菌ATCC 29213的基因组序列草图
Genome Announc. 2015 Sep 24;3(5):e01095-15. doi: 10.1128/genomeA.01095-15.
5
The re-emergence of natural products for drug discovery in the genomics era.基因组学时代天然产物在药物发现中的再兴起。
Nat Rev Drug Discov. 2015 Feb;14(2):111-29. doi: 10.1038/nrd4510. Epub 2015 Jan 23.
6
Reconstructing fungal natural product biosynthetic pathways.重建真菌天然产物生物合成途径。
Nat Prod Rep. 2014 Oct;31(10):1339-47. doi: 10.1039/c4np00084f.
7
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8
Overcoming the current deadlock in antibiotic research.克服抗生素研究当前的僵局。
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9
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10
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Br J Pharmacol. 2011 May;163(1):184-94. doi: 10.1111/j.1476-5381.2011.01250.x.