Mild Hyperthermia Induced by Hollow Mesoporous Prussian Blue Nanoparticles in Alliance with a Low Concentration of Hydrogen Peroxide Shows Powerful Antibacterial Effect.

The emergence of superbacteria as well as the drug resistance of the current bacteria gives rise to worry regarding a bacterial pandemic and also calls for the development of novel ways to combat the bacteria. Here in this article, we demonstrate that mild hyperthermia induced by hollow mesoporous Prussian blue nanoparticles (HMPBNPs) in alliance with a low concentration of hydrogen peroxide (HO) shows a powerful inhibition effect on bacteria. Our results demonstrate that this therapeutic regime could realize almost full growth inhibition of both Gram-positive (, ) and -negative bacteria (, ), as well as potent inhibition/elimination of the biofilm. The wound healing results indicate that combination regime of the antibacterial system could be conveniently used for wound disinfection and could promote wound healing. To our limited knowledge, this is one of the few pioneer works to apply mild hyperthermia for the combat of bacteria, which provides a novel strategy to inspire future studies.