Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Urology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Drug Deliv. 2023 Dec;30(1):1-8. doi: 10.1080/10717544.2022.2152134.
Skin infection is a major health issue that usually is caused by the continuous proliferation of bacteria in wounds. With the abuse of antibiotics worldwide, the battle against skin infection is becoming more and more difficult. Therefore, the development of new ways with different antibacterial mechanisms to current antibiotics is urgently needed. Inspired by the powerful inhibition of ferroptosis used in cancer therapy, here in our study, ferric-loaded lipid nanoparticles (Fe-LNPs) with unform size (∼130 nm) and surface charge (∼12 mV) were constructed and found to effectively inhibit the growth of both Gram positive (Staphylococcus aureus, ) and negative (Escherichia coli, ) strains, possibly due to induction of ferroptosis-like cell death mechanisms. Most importantly, Fe-LNPs can also effectively inhibit the proliferation of in a skin infection model and promote the healing of wounds. The Fe-LNPs can be applied as a powerful antibacterial formulation for future application in clinic.
皮肤感染是一个主要的健康问题，通常是由伤口中细菌的持续增殖引起的。随着世界各地抗生素的滥用，对抗皮肤感染的斗争变得越来越困难。因此，迫切需要开发具有与现有抗生素不同抗菌机制的新方法。受铁死亡在癌症治疗中强大抑制作用的启发，在本研究中，构建了具有均一尺寸（约 130nm）和表面电荷（约 12mV）的负载铁的脂质纳米颗粒（Fe-LNPs），并发现其能够有效抑制革兰氏阳性（金黄色葡萄球菌， ）和阴性（大肠杆菌， ）菌株的生长，可能是由于诱导了铁死亡样细胞死亡机制。最重要的是，Fe-LNPs 还可以有效抑制皮肤感染模型中 的增殖，并促进伤口愈合。Fe-LNPs 可作为一种强大的抗菌制剂，用于未来的临床应用。
