Hallfrisch J, Ellwood K, Michaelis O E, Reiser S, Prather E S
J Am Coll Nutr. 1986;5(1):61-8. doi: 10.1080/07315724.1986.10720113.
We fed 12 men with abnormally high insulin responses to a sucrose load and 12 controls normal diets containing 0, 7.5, or 15% of the calories as pure fructose for 5 weeks each in a crossover design. Purified wheat starch replaced the fructose in the 0 and 7.5% diets. The two groups were matched for age, height, and weight. At the beginning of the study and at the end of each of the three 5-week periods, plasma responses to a sucrose load (2 gm/kg body weight) were measured. Initially there were no significant differences in the plasma fructose, uric acid, or inorganic phosphorus responses of the two groups. Plasma fructose responses to a sucrose load were significantly higher after the men consumed the 7.5 and 15% fructose diets than after the 0% diet. Uric acid responses tended to be greater in the hyperinsulinemic men than in controls and increased as the levels of fructose in the diet increased. The inorganic phosphorus levels after a sucrose load were higher in the hyperinsulinemic men than in controls when they consumed the 7.5 and 15% fructose diets. These results indicate that moderate levels of dietary fructose can affect plasma fructose, uric acid, and inorganic phosphorus levels, especially in hyperinsulinemic men.
我们采用交叉设计，让12名对蔗糖负荷有异常高胰岛素反应的男性和12名对照组人员，分别食用含0%、7.5%或15%热量为纯果糖的正常饮食，每种饮食持续5周。在含0%和7.5%果糖的饮食中，用纯化的小麦淀粉替代果糖。两组在年龄、身高和体重方面进行了匹配。在研究开始时以及三个5周阶段结束时，测量了对蔗糖负荷（2克/千克体重）的血浆反应。最初，两组的血浆果糖、尿酸或无机磷反应没有显著差异。男性食用含7.5%和15%果糖的饮食后，对蔗糖负荷的血浆果糖反应显著高于食用0%果糖饮食后。高胰岛素血症男性的尿酸反应往往高于对照组，且随着饮食中果糖水平的增加而增加。当高胰岛素血症男性食用含7.5%和15%果糖的饮食时，蔗糖负荷后的无机磷水平高于对照组。这些结果表明，适度水平的膳食果糖会影响血浆果糖、尿酸和无机磷水平，尤其是在高胰岛素血症男性中。
