Elkhazen N, Jauniaux E, Dodion J, Vamos E, Rodesch F, Wilkin P, Milaire J
J Gynecol Obstet Biol Reprod (Paris). 1986;15(1):87-97.
24 cases of non-immune feto-placental hydrops which were diagnosed by ultrasonography are presented. The precise etiology was possible in 21 of the cases using chromosome analyses, radiological assessments and carefully conducted post mortem examinations. The cause was maternal in 3 cases and due to fetal pathology in 18 cases, of which 5 were due to chromosome abnormalities. Three recessive autosomal syndrome, 9 malformations and in particular cardiac malformations and one twin pregnancy with transfusion from one fetus to the other were diagnosed. These features, which can be compared with those already in the literature, show that most of these cases of hydrops are due to genetic fetal defects and demonstrate how important it is to carry out chromosome analyses and systematic anatomo-pathological investigations. The results of these tests will indicate the way the doctors should look after the mother during pregnancy and how to deliver these mothers in subsequent pregnancies.
本文报告了24例经超声检查诊断为非免疫性胎儿胎盘水肿的病例。通过染色体分析、放射学评估以及仔细的尸检，21例病例得以明确确切病因。病因来自母亲的有3例，因胎儿病变的有18例，其中5例是染色体异常。诊断出3种常染色体隐性综合征、9种畸形，尤其是心脏畸形，以及1例双胎妊娠中一个胎儿向另一个胎儿输血的情况。这些特征与文献中已有的特征进行比较后表明，这些水肿病例大多是由胎儿基因缺陷引起的，同时也证明了进行染色体分析和系统解剖病理学调查的重要性。这些检查结果将为医生在孕期照顾母亲以及后续妊娠中如何为这些母亲接生指明方向。
