Pei Yanzi, Qian Yujie, Wang Hao, Tan Li
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Front Oncol. 2022 Jan 31;12:771870. doi: 10.3389/fonc.2022.771870. eCollection 2022.
Ferroptosis is an evolutionarily conserved form of regulated cell death triggered by iron-dependent phospholipid peroxidation. Ferroptosis contributes to the maintenance of tissue homeostasis under physiological conditions while its aberration is tightly connected with lots of pathophysiological processes such as acute tissue injury, chronic degenerative disease, and tumorigenesis. Epigenetic regulation controls chromatin structure and gene expression by writing/reading/erasing the covalent modifications on DNA, histone, and RNA, without altering the DNA sequence. Accumulating evidences suggest that epigenetic regulation is involved in the determination of cellular vulnerability to ferroptosis. Here, we summarize the recent advances on the epigenetic mechanisms that control the expression of ferroptosis-associated genes and thereby the ferroptosis process. Moreover, the potential value of epigenetic drugs in targeting or synergizing ferroptosis during cancer therapy is also discussed.
铁死亡是一种由铁依赖性磷脂过氧化引发的进化上保守的程序性细胞死亡形式。在生理条件下，铁死亡有助于维持组织稳态，而其异常与许多病理生理过程密切相关，如急性组织损伤、慢性退行性疾病和肿瘤发生。表观遗传调控通过写入/读取/擦除DNA、组蛋白和RNA上的共价修饰来控制染色质结构和基因表达，而不改变DNA序列。越来越多的证据表明，表观遗传调控参与了细胞对铁死亡易感性的决定。在此，我们总结了控制铁死亡相关基因表达从而调控铁死亡过程的表观遗传机制的最新进展。此外，还讨论了表观遗传药物在癌症治疗中靶向或协同铁死亡的潜在价值。
