Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, 13496, Republic of Korea.
Department of Biomedical Science, General Graduate School, CHA University, Seongnam, Republic of Korea.
Cell Oncol (Dordr). 2023 Dec;46(6):1605-1623. doi: 10.1007/s13402-023-00840-7. Epub 2023 Jul 12.
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can eliminate these oxidized lipids and prevent disrupting the integrity of cell membranes. Epigenetic modifications can regulate ferroptosis by altering gene expression or cell phenotype without permanent sequence changes. These mechanisms include DNA methylation, histone modifications, RNA modifications, and noncoding RNAs. Epigenetic alterations in cancer can control the expression of ferroptosis regulators or related pathways, leading to changes in cell sensitivity to ferroptosis inducers or cancer progression. Epigenetic alterations in cancer are influenced by a wide range of cancer hallmarks, contributing to therapeutic resistance. Targeting epigenetic alterations is a promising approach to overcoming cancer resilience. However, the exact mechanisms involved in different types of cancer remain unresolved. Discovering more ferroptosis-associated epigenetic targets and interventions can help overcome current barriers in anticancer therapy. Many papers on epigenetic modifications of ferroptosis have been continuously published, making it essential to summarize the current state-of-the-art in the epigenetic regulation of ferroptosis in human cancer.
铁死亡是一种新发现的受氧化调控的细胞死亡形式，其发生与铁介导的脂质过氧化积累有关。自由基捕获抗氧化系统可以消除这些氧化脂质，防止破坏细胞膜的完整性。表观遗传修饰可以通过改变基因表达或细胞表型而不引起永久序列改变来调节铁死亡。这些机制包括 DNA 甲基化、组蛋白修饰、RNA 修饰和非编码 RNA。癌症中的表观遗传改变可以控制铁死亡调节剂或相关途径的表达，导致细胞对铁死亡诱导剂的敏感性或癌症进展发生变化。癌症中的表观遗传改变受到多种癌症特征的影响，导致治疗耐药性。针对表观遗传改变是克服癌症耐药性的一种有前途的方法。然而，不同类型癌症中涉及的确切机制仍未解决。发现更多与铁死亡相关的表观遗传靶标和干预措施，有助于克服当前癌症治疗中的障碍。关于铁死亡的表观遗传修饰的论文不断发表，因此有必要总结人类癌症中铁死亡的表观遗传调控的最新进展。
