Aghakhani Ladan, Haghighat Neda, Amini Masoud, Hosseini Seyed Vahid, Masoumi Seyed Jalil
Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Laparoscopy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Gastroenterol Res Pract. 2022 Feb 7;2022:5980390. doi: 10.1155/2022/5980390. eCollection 2022.
Nonalcoholic fatty liver disease (NAFLD) is common in severely obese individuals undergoing bariatric surgery. Assessing the prevalence and severity of NAFLD seems crucial since it may affect the prevention or development of more severe forms of fatty liver.
This cross-sectional study was conducted on 228 severely obese individuals undergoing bariatric surgery. Abdominal ultrasonography was done, and clinical and biochemical factors (liver enzymes, lipid profile, and fasting blood sugar (FBS)) were assessed.
The mean body mass index (BMI) was 43.45 ± 5.92 kg/m. The prevalence of NAFLD was 49.12% (mild steatosis: 37.5%, moderate steatosis: 36.6%, and severe steatosis: 25.8%). The main risk factors of NAFLD were weight ( = 0.002), BMI ( = 0.003), alanine aminotransferase (ALT) ( < 0.001), aspartate aminotransferase (AST) ( < 0.001), serum triglycerides (TGs) ( = 0.004), and FBS ( = 0.039). The results revealed a statistically significant decrease in the mean level of high-density lipoprotein cholesterol (HDL-C) ( = 0.044). However, no significant association was found between the severity of liver steatosis and the presence of comorbidities such as hypertension, diabetes, hypothyroidism, and dyslipidemia.
More severe NAFLD was associated with increased weight and BMI. Elevated ALT, AST, TG, and FBS levels and decreased HDL-C levels were also the risk factors of NAFLD and its progress to more severe conditions.
非酒精性脂肪性肝病（NAFLD）在接受减肥手术的严重肥胖个体中很常见。评估NAFLD的患病率和严重程度似乎至关重要，因为它可能影响更严重形式脂肪肝的预防或发展。
本横断面研究对228例接受减肥手术的严重肥胖个体进行。进行腹部超声检查，并评估临床和生化因素（肝酶、血脂谱和空腹血糖（FBS））。
平均体重指数（BMI）为43.45±5.92kg/m。NAFLD的患病率为49.12%（轻度脂肪变性：37.5%，中度脂肪变性：36.6%，重度脂肪变性：25.8%）。NAFLD的主要危险因素为体重（=0.002）、BMI（=0.003）、丙氨酸氨基转移酶（ALT）（<0.001）、天冬氨酸氨基转移酶（AST）（<0.001）、血清甘油三酯（TGs）（=0.004）和FBS（=0.039）。结果显示高密度脂蛋白胆固醇（HDL-C）平均水平有统计学显著下降（=0.044）。然而，未发现肝脂肪变性严重程度与高血压、糖尿病、甲状腺功能减退和血脂异常等合并症之间存在显著关联。
更严重的NAFLD与体重和BMI增加有关。ALT、AST、TG和FBS水平升高以及HDL-C水平降低也是NAFLD及其进展为更严重情况的危险因素。
