Sweet Patrick H, Khoo Teresa, Nguyen Steven
Family Medicine, University of California, Riverside, 555 Tachevah Drive, 2E-204, Palm Springs, CA 92262, USA.
Family Medicine Residency in Palm Springs, University of California, Riverside, 555 Tachevah Drive, 2E-204, Palm Springs, CA 92262, USA.
Prim Care. 2017 Dec;44(4):599-607. doi: 10.1016/j.pop.2017.07.003.
Nonalcoholic fatty liver disease (NAFLD) defines a condition of hepatic steatosis with or without hepatic injury. NAFLD is increasing in prevalence worldwide and presents a public health burden. Most patients are asymptomatic, although some present with fatigue and right upper quadrant pain. NAFLD is discovered incidentally when patients have elevated liver enzymes or fatty liver is seen on imaging modalities. Imaging studies can confirm fatty deposits in the liver, but needle biopsy is needed to determine degree of inflammation. The mainstay of treatment is weight loss and controlling diabetes and hyperlipidemia. Liver transplantation is considered when disease progresses to cirrhosis.
非酒精性脂肪性肝病（NAFLD）指伴有或不伴有肝损伤的肝脂肪变性情况。NAFLD在全球的患病率正在上升，并带来了公共卫生负担。大多数患者无症状，尽管有些患者会出现疲劳和右上腹疼痛。当患者肝酶升高或影像学检查发现脂肪肝时，NAFLD被偶然发现。影像学研究可以证实肝脏中的脂肪沉积，但需要进行肝穿刺活检来确定炎症程度。治疗的主要方法是减肥以及控制糖尿病和高脂血症。当疾病进展为肝硬化时，考虑进行肝移植。
