Yang Peng-Fei, Wang Chun-Rui, Hao Fa-Bao, Peng Yang, Wu Jing-Jing, Sun Wei-Ping, Hu Jie-Jun, Zhong Guo-Chao
Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Infectious Diseases, Institute for Viral Hepatitis, the Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Nutr Rev. 2022 Jun 9;80(7):1739-1754. doi: 10.1093/nutrit/nuac002.
Current dietary guidelines recommend eggs as a part of a healthy diet. However, whether egg consumption is associated with risk of mortality remains controversial. Moreover, the dose-response association of egg consumption with risk of mortality has not been determined.
To determine the potential dose-response association of egg consumption with risk of mortality in the general population.
The PubMed and Embase databases were searched for publications meeting eligibility criteria through November 2021.
Required data were extracted by 1 reviewer and then checked for accuracy by another reviewer. A random-effects dose-response meta-regression model was used to calculate the pooled risk estimates. A restricted cubic spline model was used to test nonlinearity. The certainty of evidence was assessed using the GRADE system.
Nineteen prospective cohort studies, involving 1 737 893 participants, were included. The pooled hazard ratios for an increase of 1 egg/d were 1.08 (95%CI, 1.01-1.15) for all-cause mortality, 1.07 (95%CI, 0.97-1.18) for cardiovascular disease-caused mortality, and 1.16 (95%CI, 1.04-1.30) for cancer-caused mortality. The certainty of evidence for these observations was rated as very low. Nonlinear dose-response associations were found for egg consumption and all-cause, cardiovascular disease-caused, and cancer-caused mortality. Moreover, the positive association between egg consumption and all-cause mortality was more pronounced in studies with adjustment for blood cholesterol-related covariates than those without (Pinteraction = 0.011).
Greater amount of egg consumption confers higher risks of death from all causes, cardiovascular disease, and canc er in a nonlinear dose-response pattern. These findings should be treated with caution and need to be confirmed by future studies.
当前的饮食指南建议将鸡蛋作为健康饮食的一部分。然而，食用鸡蛋是否与死亡风险相关仍存在争议。此外，鸡蛋摄入量与死亡风险之间的剂量反应关系尚未确定。
确定一般人群中鸡蛋摄入量与死亡风险之间潜在的剂量反应关系。
检索了PubMed和Embase数据库，以获取截至2021年11月符合纳入标准的出版物。
由1名审阅者提取所需数据，然后由另一名审阅者检查准确性。采用随机效应剂量反应meta回归模型计算合并风险估计值。使用受限立方样条模型检验非线性。使用GRADE系统评估证据的确定性。
纳入了19项前瞻性队列研究，涉及1737893名参与者。每天增加1个鸡蛋的全因死亡率合并风险比为1.08（95%CI，1.01-1.15），心血管疾病导致的死亡率为1.07（95%CI，0.97-1.18），癌症导致的死亡率为1.16（95%CI，1.04-1.30）。这些观察结果的证据确定性被评为非常低。发现鸡蛋摄入量与全因、心血管疾病导致的和癌症导致的死亡率之间存在非线性剂量反应关系。此外，在对血液胆固醇相关协变量进行调整的研究中，鸡蛋摄入量与全因死亡率之间的正相关比未进行调整的研究更明显（P交互作用 = 0.011）。
鸡蛋摄入量增加会以非线性剂量反应模式带来更高的全因、心血管疾病和癌症死亡风险。这些发现应谨慎对待，需要未来的研究加以证实。
