白术中新的桉烷倍半萜类化合物及其对固醇调节元件结合蛋白的抑制活性

[New eudesmane sesquiterpenoids from Atractylodis Macrocephalae Rhizoma and their inhibitory activities against SREBPs].

作者信息

Xu Rui-Zhu, Zhao Xuan, DU Yue-Yue, Xu Meng-Sha, Liu Xin-Guang, Xie Zhi-Shen, Gao Song, Xu Jiang-Yan, Wang Pan

机构信息

Academy of Chinese Medical Sciences, Henan University of Chinese Medicine Zhengzhou 450046, China School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China.

School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2022 Jan;47(2):428-432. doi: 10.19540/j.cnki.cjcmm.20211014.201.

DOI:10.19540/j.cnki.cjcmm.20211014.201

PMID:35178985

Abstract

Three sesquiterpenoids were isolated and purified from the 95% ethanol extract of Atractylodis Macrocephalae Rhizoma by column chromatography on silica gel, Sephadex LH-20, ODS, and high-performance liquid chromatography(HPLC). Their chemical structures were identified on the basis of spectroscopic analysis and physiochemical properties as(7Z)-8β,13-diacetoxy-eudesma-4(15),7(11)-diene(1), 7-oxo-7,8-secoeudesma-4(15),11-dien-8-oic acid(2), and guai-10(14)-en-11-ol(3). Compounds 1 and 2 are new compounds and compound 3 was obtained from Compositae family for the first time. Compounds 1, 2, and 3 showed weak inhibitory activities against sterol regulatory element-binding proteins(SREBPs).

摘要

通过硅胶柱色谱、葡聚糖凝胶LH - 20、ODS柱色谱以及高效液相色谱（HPLC），从白术95%乙醇提取物中分离并纯化出三种倍半萜类化合物。基于光谱分析和理化性质，确定它们的化学结构分别为(7Z)-8β,13 - 二乙酰氧基 - 桉叶 - 4(15),7(11) - 二烯（1）、7 - 氧代 - 7,8 - 断桉叶 - 4(15),11 - 二烯 - 8 - 酸（2）和愈创木 - 10(14) - 烯 - 11 - 醇（3）。化合物1和2为新化合物，化合物3首次从菊科植物中获得。化合物1、2和3对固醇调节元件结合蛋白（SREBPs）表现出较弱的抑制活性。