小鼠免疫球蛋白M与葡萄球菌A蛋白的结合。
The binding of murine IgM to Staphylococcal A protein.
作者信息
MacKenzie M R, Gutman G A, Warner N L
出版信息
Scand J Immunol. 1978;7(5):367-70. doi: 10.1111/j.1365-3083.1978.tb00466.x.
Abstract
The binding of Staph A protein to murine immunoglobulins has previously been thought to be restricted to the IgG2 and IgG3 classes. In this study five IgM proteins were assessed for binding, and of these one showed marked Staph A binding. Pepsin digestion of this IgM molecule produced several different sized fragments, and the binding studies with these fragments indicated that the binding site is in the CH2 domain.
摘要
葡萄球菌A蛋白与鼠免疫球蛋白的结合此前一直被认为仅限于IgG2和IgG3类。在本研究中，对五种IgM蛋白进行了结合评估，其中一种显示出与葡萄球菌A蛋白有明显的结合。用胃蛋白酶消化该IgM分子产生了几种不同大小的片段，对这些片段的结合研究表明结合位点在CH2结构域。
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