Hohmann E L, Elde R P, Rysavy J A, Einzig S, Gebhard R L
Science. 1986 May 16;232(4752):868-71. doi: 10.1126/science.3518059.
Neural control of bone metabolism and growth has been suggested, although the identity of participating neurons and neurotransmitters effecting this control has not been established. Immunohistochemical studies demonstrated a system of vasoactive intestinal peptide (VIP)-immunoreactive nerve fibers that innervate periosteum and bone in several mammalian species. Thoracic sympathetic chain ganglionectomy resulted in an ipsilateral loss of VIP-immunoreactive fibers in the periosteum of ribs, whereas dorsal root ganglionectomy had no effect. Injection of fast blue into rib periosteum labeled a population of VIP-immunoreactive sympathetic postganglionic neurons. Thus, postganglionic sympathetic neurons may provide an important means by which VIP regulates bone mineralization.
虽然尚未确定参与这种控制的神经元和神经递质的身份，但已有研究表明存在对骨代谢和生长的神经控制。免疫组织化学研究显示，在几种哺乳动物中，存在一个由血管活性肠肽（VIP）免疫反应性神经纤维组成的系统，该系统支配骨膜和骨骼。胸交感神经链神经节切除术导致肋骨骨膜中VIP免疫反应性纤维同侧缺失，而背根神经节切除术则没有影响。将快蓝注射到肋骨骨膜中标记了一群VIP免疫反应性交感神经节后神经元。因此，交感神经节后神经元可能是VIP调节骨矿化的重要途径。
