Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8383-8394. doi: 10.1002/anie.201800594. Epub 2018 May 8.
Featuring high biocompatibility, the emerging field of gas therapy has attracted extensive attention in the medical and scientific communities. Currently, considerable research has focused on the gasotransmitter nitric oxide (NO) owing to its unparalleled dual roles in directly killing cancer cells at high concentrations and cooperatively sensitizing cancer cells to other treatments for synergistic therapy. Of particular note, recent state-of-the-art studies have turned our attention to the chemical design of various endogenous/exogenous stimuli-responsive NO-releasing nanomedicines and their biomedical applications for on-demand NO-sensitized synergistic cancer therapy, which are discussed in this Minireview. Moreover, the potential challenges regarding NO gas therapy are also described, aiming to advance the development of NO nanomedicines as well as usher in new frontiers in this fertile research area.
具有高生物相容性的气体治疗领域在医学和科学界引起了广泛关注。目前，由于气体传递体一氧化氮（NO）在高浓度下直接杀死癌细胞的独特双重作用，以及与其他治疗方法协同作用以实现协同治疗的能力，大量研究集中在 NO 上。值得注意的是，最近的最先进研究引起了我们对各种内源性/外源性刺激响应性 NO 释放纳米药物的化学设计及其用于按需 NO 敏化协同癌症治疗的生物医学应用的关注，这在本综述中进行了讨论。此外，还描述了 NO 气体治疗的潜在挑战，旨在推进 NO 纳米药物的发展，并为这一富有成效的研究领域开辟新的前沿。
