Critical Care and Resuscitation Research, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York.
Department of Family, Population and Preventive Medicine, Stony Brook Medical Center, State University of New York at Stony Brook, New York, New York.
Ann N Y Acad Sci. 2022 May;1511(1):5-21. doi: 10.1111/nyas.14740. Epub 2022 Feb 18.
An inadvertent consequence of advances in stem cell research, neuroscience, and resuscitation science has been to enable scientific insights regarding what happens to the human brain in relation to death. The scientific exploration of death is in large part possible due to the recognition that brain cells are more resilient to the effects of anoxia than assumed. Hence, brain cells become irreversibly damaged and "die" over hours to days postmortem. Resuscitation science has enabled life to be restored to millions of people after their hearts had stopped. These survivors have described a unique set of recollections in relation to death that appear universal. We review the literature, with a focus on death, the recalled experiences in relation to cardiac arrest, post-intensive care syndrome, and related phenomena that provide insights into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We also identify issues and controversies related to the study of consciousness and the recalled experience of cardiac arrest and death in subjects who have been in a coma, with a view to standardize and facilitate future research.
干细胞研究、神经科学和复苏科学的进展带来了一个意想不到的后果，使人们能够深入了解与死亡相关的人类大脑的变化。对死亡的科学探索在很大程度上是由于认识到脑细胞对缺氧的影响比想象的更具弹性。因此，脑细胞会在死后数小时到数天内不可逆转地受损并“死亡”。复苏科学使数百万心脏停止跳动的人得以恢复生命。这些幸存者描述了与死亡相关的一组独特的回忆，这些回忆似乎是普遍存在的。我们回顾了文献，重点关注死亡、与心脏骤停相关的回忆体验、重症监护后综合征以及相关现象，这些现象为深入了解潜在机制、伦理影响以及系统研究的方法学考虑提供了线索。我们还确定了与昏迷状态下心脏骤停和死亡的意识和回忆体验研究相关的问题和争议，以期对未来的研究进行标准化和促进。
