KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada.
Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada.
Syst Rev. 2022 Feb 19;11(1):31. doi: 10.1186/s13643-021-01874-4.
High-intensity interval training (HIIT) has shown to confer cognitive benefits in healthy adults, via a mechanism purportedly driven by the exercise metabolite lactate. However, our understanding of the exercise parameters (e.g., work interval duration, session volume, work-to-rest ratio) that evoke a peak blood lactate response in healthy adults is limited. Moreover, evidence relating HIIT-induced blood lactate and cognitive performance has yet to be reviewed and analyzed. The primary objective of this systematic review is to use network meta-analyses to compare the relative impact of different HIIT work-interval durations, session volumes, and work-to-rest ratios on post-exercise blood lactate response in healthy adults. The secondary objective is to determine the relationship between HIIT-induced blood lactate and acute post-HIIT cognitive performance.
A systematic review is being conducted to identify studies measuring blood lactate response following one session of HIIT in healthy adults. The search was carried out in (1) MEDLINE, (2) EMBASE, (3) Cochrane Central Register of Controlled Trials, (4) Sport Discus, and (5) Cumulative Index to Nursing and Allied Health Literature Plus with Full Text (CINAHL+). After abstract and full-text screening, two reviewers will independently extract data on key outcomes variables and complete risk of bias assessment using the Cochrane Risk of Bias Tool and the Risk of Bias in Non-Randomized Studies of Interventions tool. Network meta-analyses will be used to generate estimates of the comparative effectiveness of blood lactate on cognitive outcomes using corresponding rankings for each work-interval duration, session volume, and work-to-rest ratio category. Where applicable, meta-regressions analyses will be performed to test the relationship between changes in the blood lactate and changes in cognitive performance. Analyses will be conducted using MetaInsight Software.
This study will provide evidence on how to structure a HIIT protocol to elicit peak blood lactate response in healthy adults and will increase our understanding of the relationship between HIIT-induced blood lactate response and associated cognitive benefits.
PROSPERO CRD42020204400.
高强度间歇训练（HIIT）已被证明可以通过运动代谢产物乳酸来提高健康成年人的认知能力，但我们对引起健康成年人血液中乳酸峰值反应的运动参数（例如工作间隔持续时间、训练量、工作与休息比）的理解有限。此外，HIIT 引起的血液乳酸与认知表现之间的关系尚未得到综述和分析。本系统综述的主要目的是使用网络荟萃分析比较不同 HIIT 工作间隔持续时间、训练量和工作与休息比在健康成年人运动后血液中乳酸反应的相对影响。次要目的是确定 HIIT 诱导的血液乳酸与急性 HIIT 后认知表现之间的关系。
正在进行系统综述，以确定测量健康成年人单次 HIIT 后血液乳酸反应的研究。检索了（1）MEDLINE、（2）EMBASE、（3）Cochrane 对照试验中心注册库、（4）运动文献数据库和（5）护理与联合健康文献累积索引全文数据库（CINAHL+）。经过摘要和全文筛选后，两名审查员将独立提取关键结局变量的数据，并使用 Cochrane 偏倚风险工具和干预措施非随机研究偏倚风险工具完成偏倚风险评估。将使用网络荟萃分析生成血液乳酸对认知结果的相对有效性估计，为每个工作间隔持续时间、训练量和工作与休息比类别生成相应的排名。在适用的情况下，将进行荟萃回归分析以检验血液乳酸变化与认知表现变化之间的关系。分析将使用 MetaInsight 软件进行。
本研究将提供关于如何构建 HIIT 方案以引起健康成年人血液中乳酸峰值反应的证据，并增加我们对 HIIT 诱导的血液乳酸反应与相关认知益处之间关系的理解。
PROSPERO CRD42020204400。
