Mochizuki Takeshi, Hori Takaki, Yano Koichiro, Ikari Katsunori, Okazaki Ken
Department of Rheumatology and Orthopedic Surgery, Kamagaya General Hospital, Japan.
Department of Cardiovascular Surgery, Kamagaya General Hospital, Japan.
Intern Med. 2022 Apr 15;61(8):1139-1143. doi: 10.2169/internalmedicine.8902-21. Epub 2022 Feb 19.
Objective We evaluated the change in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers from three to six months after the administration of the BNT162b2 vaccine among healthcare workers. Methods A total of 337 healthcare workers who received 2 doses of the BNT162b2 vaccine were included in this study. Factors associated with SARS-CoV-2 antibody titers at three and six months and the change in SARS-CoV-2 antibody titers between three and six months after vaccine administration were analyzed using a logistic regression analysis. Results The SARS-CoV-2 antibody titer at 3 months was 4,812.1±3,762.9 AU/mL in all subjects and was lower in older workers than in younger ones. The SARS-CoV-2 antibody titer at 6 months was 1,368.9±1,412.3 AU/mL in all subjects. The SARS-CoV-2 antibody titers that were found to be high at three months were also high at six months. The change in SARS-CoV-2 antibody titers from 3 to 6 months was -68.9%±16.1%. The higher SARS-CoV-2 antibody titers at three months showed a more marked decrease from three to six months than lower titers. Conclusion This study demonstrates that SARS-CoV-2 antibody titers at three months decreased with age and were associated with the antibody titers at six months and the change in titer from three to six months. Older individuals in particular need to be aware of the declining SARS-CoV-2 antibody titers at six months after the BNT162b2 vaccine. The results of this study may provide insight into COVID-19 vaccine booster strategies.
目的 我们评估了医护人员接种BNT162b2疫苗后3至6个月严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抗体滴度的变化。方法 本研究纳入了337名接种2剂BNT162b2疫苗的医护人员。采用逻辑回归分析方法分析了与接种疫苗后3个月和6个月时SARS-CoV-2抗体滴度相关的因素以及3至6个月期间SARS-CoV-2抗体滴度的变化。结果 所有受试者在3个月时的SARS-CoV-2抗体滴度为4812.1±3762.9 AU/mL，老年医护人员的抗体滴度低于年轻医护人员。所有受试者在6个月时的SARS-CoV-2抗体滴度为1368.9±1412.3 AU/mL。在3个月时抗体滴度高的受试者在6个月时抗体滴度也高。SARS-CoV-2抗体滴度从3个月到6个月的变化为-68.9%±16.1%。3个月时SARS-CoV-2抗体滴度越高，从3个月到6个月的下降幅度比低滴度者更明显。结论 本研究表明，3个月时的SARS-CoV-2抗体滴度随年龄增长而降低，并且与6个月时的抗体滴度以及3至6个月期间滴度的变化有关。特别是老年人需要注意在接种BNT162b2疫苗6个月后SARS-CoV-2抗体滴度的下降情况。本研究结果可能为2019冠状病毒病（COVID-19）疫苗加强策略提供见解。
