Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Endocr J. 2022 Jul 28;69(7):839-846. doi: 10.1507/endocrj.EJ21-0591. Epub 2022 Feb 18.
Evidence about the relationship between Helicobacter pylori (Hp) infection and type 2 diabetes mellitus (T2DM) is inconsistent and contradictory. This study attempted to investigate this association in the middle-aged and elderly Chinese population and analyze the joint effects of Hp infection and some risk factors on T2DM. Following a cross-sectional design, participants were recruited from the First Affiliated Hospital of Anhui Medical University in Hefei City, China. Hp status was measured using a C urea breath test. A total of 1,288 participants, including 90 diabetic patients and 1,198 nondiabetic subjects, were recruited in the current study. The participants with T2DM had a greater prevalence of Hp infection than participants without T2DM (26.67% versus 18.11%, p = 0.045). Furthermore, we found that Hp infection was closely associated with an incremental risk of T2DM [odds ratio (OR) = 1.77, 95% confidence intervals (CI): 1.04-3.00] after adjustment for potential confounders. In addition, we observed that the participants who were Hp-positive and ≥60 years old (OR = 9.16, 95% CI: 3.29-25.52), Hp-positive and obese (OR = 3.35, 95% CI: 1.57-7.14) or Hp-positive and hypertensive (OR = 6.10, 95% CI: 3.10-12.01) had a significantly higher risk for T2DM than those who were Hp-negative and ≤50 years old, Hp-negative and nonobese or Hp-negative and nonhypertensive. These findings imply that Hp infection is associated with an increased risk of T2DM in the middle-aged and elderly Chinese population. The association could be further elevated by the combination of Hp infection and some traditional risk factors.
幽门螺杆菌（Hp）感染与 2 型糖尿病（T2DM）之间的关系证据不一致且相互矛盾。本研究试图在中国中老年人群中探讨这种相关性，并分析 Hp 感染和一些危险因素对 T2DM 的联合作用。采用横断面设计，从中国合肥市安徽医科大学第一附属医院招募参与者。Hp 状态采用 C 尿素呼气试验进行测量。本研究共纳入 1288 名参与者，包括 90 名糖尿病患者和 1198 名非糖尿病患者。患有 T2DM 的参与者的 Hp 感染率高于未患有 T2DM 的参与者（26.67%比 18.11%，p = 0.045）。此外，我们发现，在调整了潜在混杂因素后，Hp 感染与 T2DM 的发生风险呈正相关[比值比（OR）=1.77，95%置信区间（CI）：1.04-3.00]。此外，我们观察到，Hp 阳性且年龄≥60 岁（OR=9.16，95%CI：3.29-25.52）、Hp 阳性且肥胖（OR=3.35，95%CI：1.57-7.14）或 Hp 阳性且高血压（OR=6.10，95%CI：3.10-12.01）的参与者发生 T2DM 的风险显著高于 Hp 阴性且年龄≤50 岁、Hp 阴性且非肥胖或 Hp 阴性且非高血压的参与者。这些发现表明，在中国中老年人群中，Hp 感染与 T2DM 的发生风险增加有关。这种相关性可能因 Hp 感染与一些传统危险因素的结合而进一步升高。
