Research Center for Translational Medicine, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Department of Gastroenterology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Sci Rep. 2019 Mar 19;9(1):4874. doi: 10.1038/s41598-019-41371-2.
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese adults in 2015. C-urea breath tests were used to determine HP infection status. Abdominal ultrasonography was performed to diagnose NAFLD. Multivariable logistic regression was conducted to identify the association between HP infection and NAFLD. A total of 4081 individuals were included in this study; 2137 (52.36%) participants were HP-positive, and 1022 (47.82%) were diagnosed with NAFLD in HP-positive individuals. The odds ratios (OR) and 95% confidence intervals (CI) of participants with HP infection for NAFLD were 1.20 (1.06-1.36) in crude model and 1.27 (1.07-1.50) in fully adjusted model. When stratified by sex and dyslipidemia, the fully adjusted OR and 95% CI for NAFLD were 1.22 (1.10-1.80) in females and 1.44 (1.18-1.75) in subjects with dyslipidemia. There were not significant increased OR for NAFLD when stratified by age. The study indicate that HP infection is associated with NAFLD, particularly in females and patients with dyslipidemia, suggesting that HP eradication might be an alternative method for the prevention or treatment of NAFLD treatment.
非酒精性脂肪性肝病（NAFLD）是一种常见的肝脏疾病。先前关于幽门螺杆菌（HP）感染与 NAFLD 之间关联的研究结果并不一致。本研究旨在探讨 HP 感染与 NAFLD 之间的关系。我们于 2015 年在中国北方成年人中进行了一项大型横断面研究。采用 C-尿素呼气试验来确定 HP 感染状况。通过腹部超声检查来诊断 NAFLD。采用多变量逻辑回归来确定 HP 感染与 NAFLD 之间的关联。本研究共纳入了 4081 名参与者；其中 2137 名（52.36%）参与者为 HP 阳性，1022 名（47.82%）HP 阳性者被诊断为 NAFLD。在未经调整模型中，HP 感染参与者患 NAFLD 的比值比（OR）和 95%置信区间（CI）为 1.20（1.06-1.36），在完全调整模型中为 1.27（1.07-1.50）。按性别和血脂异常分层后，女性和血脂异常患者中完全调整后的 OR 和 95%CI 分别为 1.22（1.10-1.80）和 1.44（1.18-1.75）。按年龄分层时，NAFLD 的 OR 没有显著增加。本研究表明，HP 感染与 NAFLD 相关，特别是在女性和血脂异常患者中，提示 HP 根除可能是预防或治疗 NAFLD 的一种替代方法。
