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眼前节异常对青光眼DBA/2J小鼠模型眼压变化的影响：DBA/2J - /SjJ小鼠作为关键对照。

The Contribution of Anterior Segment Abnormalities to Changes in Intraocular Pressure in the DBA/2J Mouse Model of Glaucoma: DBA/2J- /SjJ Mice as Critical Controls.

作者信息

Rohowetz Landon J, Mardelli Marc E, Duncan R Scott, Riordan Sean M, Koulen Peter

机构信息

Department of Ophthalmology, Vision Research Center, School of Medicine, University of Missouri - Kansas City, Kansas City, MO, United States.

Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, United States.

出版信息

Front Neurosci. 2022 Feb 3;15:801184. doi: 10.3389/fnins.2021.801184. eCollection 2021.

DOI:10.3389/fnins.2021.801184
PMID:35185449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8850401/
Abstract

The contributions of anterior segment abnormalities to the development of ocular hypertension was determined in the DBA/2J mouse model of glaucoma. Intraocular pressure (IOP) was measured non-invasively. Iris pigment dispersion (IPD) and corneal calcification were measured weekly starting at 20 weeks of age in DBA/2J and DBA/2J- /SjJ mice. Thickness, surface area, auto-fluorescence intensity, and perimeter length of calcified regions were measured in postmortem corneas using confocal microscopy. DBA/2J mice developed elevated IOP between 9 and 12 months of age, but DBA/2J- /SjJ mice did not. Corneal calcification was found at all ages observed and at similar frequencies in both strains with 83.3% of DBA/2J eyes and 60.0% of DBA/2J- /SjJ eyes affected at 12 months ( = 0.11). Calcification increased with age in both DBA/2J ( = 0.049) and DBA/2J- /SjJ mice ( = 0.04) when assessed qualitatively and based on mixed-effects analysis. No differences in the four objective measures of calcification were observed between strains or ages. At 12 months of age, DBA/2J mice with corneal calcification had greater mean IOP than DBA/2J mice without corneal calcification. IOP was not correlated with the qualitatively assessed measures of calcification. For the subset of eyes with ocular hypertension, which were only found in DBA/2J mice, IOP was negatively correlated with the qualitative degree of calcification, but was not correlated with the four quantitative measures of calcification. Differences in IOP were not observed between DBA/2J- /SjJ mice with and without calcification at any age. IPD increased with age and demonstrated a moderate correlation with IOP in DBA/2J mice, but was not observed in DBA/2J- /SjJ mice. In the DBA/2J mouse model of glaucoma, increased IPD is positively correlated with an increase in IOP and corneal calcification is present in the majority of eyes at and after age 9 months. However, while IPD causes ocular hypertension, corneal calcification does not appear to contribute to the elevation of IOP, as the control strain DBA/2J- /SjJ exhibits corneal calcification similar to DBA/2J mice, but does not develop ocular hypertension. Corneal calcification, therefore, does not appear to be a contributing factor to the development of elevated IOP in DBA/2J mice.

摘要

在青光眼的DBA/2J小鼠模型中，确定了眼前节异常对高眼压发展的影响。采用非侵入性方法测量眼压（IOP）。从20周龄开始，每周对DBA/2J和DBA/2J - /SjJ小鼠的虹膜色素播散（IPD）和角膜钙化情况进行测量。使用共聚焦显微镜在死后的角膜中测量钙化区域的厚度、表面积、自发荧光强度和周长。DBA/2J小鼠在9至12月龄时眼压升高，但DBA/2J - /SjJ小鼠未出现这种情况。在观察的所有年龄段均发现了角膜钙化，且两个品系的发生率相似，12月龄时，83.3%的DBA/2J小鼠眼睛和60.0%的DBA/2J - /SjJ小鼠眼睛受到影响（P = 0.11）。定性评估并基于混合效应分析时，DBA/2J小鼠（P = 0.049）和DBA/2J - /SjJ小鼠（P = 0.04）的钙化均随年龄增加。在品系或年龄之间，未观察到钙化的四项客观测量指标存在差异。12月龄时，有角膜钙化的DBA/2J小鼠的平均眼压高于无角膜钙化的DBA/2J小鼠。眼压与定性评估的钙化指标无关。对于仅在DBA/2J小鼠中发现的高眼压眼睛亚组，眼压与定性钙化程度呈负相关，但与钙化的四项定量测量指标无关。在任何年龄，有和无钙化的DBA/2J - /SjJ小鼠之间均未观察到眼压差异。IPD随年龄增加，且在DBA/2J小鼠中与眼压呈中度相关，但在DBA/2J - /SjJ小鼠中未观察到这种情况。在青光眼的DBA/2J小鼠模型中，IPD增加与眼压升高呈正相关，9月龄及之后的大多数眼睛中存在角膜钙化。然而，虽然IPD导致高眼压，但角膜钙化似乎并未导致眼压升高，因为对照品系DBA/2J - /SjJ表现出与DBA/2J小鼠相似的角膜钙化，但未出现高眼压。因此，角膜钙化似乎不是DBA/2J小鼠眼压升高发展的一个促成因素。

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Mol Neurobiol. 2019 Oct;56(10):7097-7112. doi: 10.1007/s12035-019-1576-4. Epub 2019 Apr 13.
3
Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma.
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4
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.补体 C3 靶向基因治疗限制慢性小鼠青光眼的神经退行性变的发作和进展。
Mol Ther. 2018 Oct 3;26(10):2379-2396. doi: 10.1016/j.ymthe.2018.08.017. Epub 2018 Aug 24.
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Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma.年龄相关的眼睛、大脑和视动行为变化在慢性青光眼的 DBA/2J 小鼠模型中。
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6
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Clin Exp Ophthalmol. 2017 Dec;45(9):911-922. doi: 10.1111/ceo.12992. Epub 2017 Jun 13.
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10
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