Zhao Ge, Tong Yue, Luan Fei, Zhu Wenjing, Zhan Chenglin, Qin Tiantian, An Weixiao, Zeng Nan
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Pharmacol. 2022 Feb 4;13:814370. doi: 10.3389/fphar.2022.814370. eCollection 2022.
Flavonoids isolated from medicinal herbs have been utilized as valuable health-care agents due to their virous biological applications. Alpinetin is a natural flavonoid that emerges in many widely used medicinal plants, and has been frequently applied in Chinese patent drugs. Accumulated evidence has demonstrated that alpinetin possesses a broad range of pharmacological activities such as antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective, and other properties through regulating multiple signaling pathways with low systemic toxicity. However, pharmacokinetic studies have documented that alpinetin may have poor oral bioavailability correlated to its extensive glucuronidation. Currently, the reported pharmacological properties and pharmacokinetics profiles of alpinetin are rare to be scientifically reviewed. In this article, we aimed to highlight the mechanisms of action of alpinetin in various diseases to strongly support its curative potentials for prospective clinical applications. We also summarized the pharmacokinetics properties and proposed some viable strategies to convey an appreciable reference for future advances of alpinetin in drug development.
从药草中分离出的黄酮类化合物因其多种生物学应用而被用作有价值的保健剂。山姜素是一种天然黄酮类化合物，存在于许多广泛使用的药用植物中，并经常应用于中成药中。越来越多的证据表明，山姜素具有广泛的药理活性，如抗肿瘤、抗炎、保肝、心血管保护、肺保护、抗菌、抗病毒、神经保护等特性，可通过调节多种信号通路发挥作用，且全身毒性较低。然而，药代动力学研究表明，山姜素可能因其广泛的葡萄糖醛酸化作用而口服生物利用度较差。目前，关于山姜素已报道的药理特性和药代动力学概况鲜有科学综述。在本文中，我们旨在强调山姜素在各种疾病中的作用机制，以有力支持其在未来临床应用中的治疗潜力。我们还总结了其药代动力学特性，并提出了一些可行的策略，为山姜素在药物开发方面的未来进展提供有价值的参考。
