School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Institute of Zoology, University of the Punjab, Quaid-E-Azam Campus, Lahore, 54590, Pakistan.
Appl Biochem Biotechnol. 2022 Sep;194(9):4220-4243. doi: 10.1007/s12010-022-03960-2. Epub 2022 May 14.
Cancer is a global burden and mechanistically complex disease with a plethora of genetic, physiological, metabolic, and environmental alterations. The development of dietary nutraceuticals into cancer chemotherapeutics has emerged as a new paradigm in cancer treatment. Alpinetin (ALPI) is a novel flavonoid component of multiple edible and medicinal plants and possesses a wide range of biological and pharmacological activities including antibacterial, anti-hemostatic, anti-oxidative, anti-hepatotoxic, stomachic, immunosuppressive, and anti-inflammatory. Recently, ALPI has been reported as a bioactive dietary nutraceutical with promising anticancer activity in various human cancers through multiple mechanisms. The purpose of this review is to compile the data on natural sources of ALPI, and its anticancer activity including cellular targets and anticancer mechanism in various human cancers. Moreover, this review will set the stage for further design and conduct pre-clinical and clinical trials to develop ALPI into a lead structure for oncological therapy.
癌症是一种全球性的负担，其发病机制复杂，涉及大量的遗传、生理、代谢和环境改变。将膳食营养保健品开发成癌症化疗药物已成为癌症治疗的新模式。白杨素 (ALPI) 是多种食用和药用植物的新型类黄酮成分，具有广泛的生物学和药理学活性，包括抗菌、抗凝血、抗氧化、抗肝毒性、健胃、免疫抑制和抗炎作用。最近，ALPI 已被报道为一种具有生物活性的膳食营养保健品，具有通过多种机制在各种人类癌症中表现出有希望的抗癌活性。本综述的目的是汇编有关 ALPI 的天然来源及其在各种人类癌症中的抗癌活性（包括细胞靶标和抗癌机制）的数据。此外，本综述将为进一步设计和开展临床前和临床试验奠定基础，以将 ALPI 开发为肿瘤治疗的主导结构。
