Oh Dongkyu, Choi Hongyoon, Paeng Jin Chul, Kang Keon Wook, Cheon Gi Jeong
Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080 Republic of Korea.
Nucl Med Mol Imaging. 2022 Feb;56(1):52-58. doi: 10.1007/s13139-021-00723-5. Epub 2021 Nov 24.
Ga-DOTA-TOC uptake in the pancreas uncinate process is often found due to physiologic expression of somatostatin receptors (SSTR). We investigated the association of physiologic Ga-DOTA-TOC uptake in the pancreas uncinate process with blood glucose level.
Ga-DOTA-TOC PET scans acquired from 44 patients (male:female = 20:24, age = 50.8 ± 14.8y [mean ± SD]) were retrospectively analyzed. The blood glucose level (BGL) was examined before Ga-DOTA-TOC injection. Patients diagnosed with diabetes mellitus and patients with BGL over 200 mg/dl were excluded. Ga-DOTA-TOC uptake was measured by the maximum standardized uptake values (SUVmax). Additionally, SSTR-positive volume (SV) in the pancreas uncinate process was measured with two different thresholds: by SUV cutoff of 2.5 (SV) and 40% of SUVmax (SV). These measurements on Ga-DOTA-TOC PET were correlated with BGL.
The mean of SUVmax of the pancreas uncinate process was 6.51 ± 2.04. SV was 17.81 ± 7.14 cm, and SV was 18.20 ± 8.83 cm. A significant negative correlation was found between SUVmax of the pancreas uncinate process and BGL ( = -0.37, = 0.01). The ratio between SUVmax of the pancreas uncinate process and SUVmean of the pancreas body also showed a significance negative correlation with BGL ( = -0.40, = 0.01). SV ( = 0.27, = 0.07) and SV ( = -0.151, = 0.32) were not significantly correlated with BGL.
Physiologic Ga-DOTA-TOC uptake in the pancreas uncinate process was negatively correlated with BGL. Our results suggested that glycemia could affect physiologic uptake of Ga-DOTA-TOC.
由于生长抑素受体（SSTR）的生理性表达，胰腺钩突部常出现镓 - DOTA - TOC摄取。我们研究了胰腺钩突部生理性镓 - DOTA - TOC摄取与血糖水平之间的关联。
回顾性分析了44例患者（男∶女 = 20∶24，年龄 = 50.8±14.8岁[均值±标准差]）的镓 - DOTA - TOC PET扫描图像。在注射镓 - DOTA - TOC之前检测血糖水平（BGL）。排除诊断为糖尿病以及血糖水平超过200mg/dl的患者。通过最大标准化摄取值（SUVmax）测量镓 - DOTA - TOC摄取。此外，采用两种不同阈值测量胰腺钩突部的SSTR阳性体积（SV）：SUV截止值为2.5（SV）和SUVmax的40%（SV）。镓 - DOTA - TOC PET上的这些测量值与BGL进行相关性分析。
胰腺钩突部的SUVmax均值为6.51±2.04。SV为17.81±7.14cm，SV为18.20±8.83cm。发现胰腺钩突部的SUVmax与BGL之间存在显著负相关（= -0.37，= 0.01）。胰腺钩突部的SUVmax与胰腺体部的SUVmean之比也显示出与BGL存在显著负相关（= -0.40，= 0.01）。SV（= 0.27，= 0.07）和SV（= -0.151，= 0.32）与BGL无显著相关性。
胰腺钩突部生理性镓 - DOTA - TOC摄取与BGL呈负相关。我们的结果表明血糖水平可能影响镓 - DOTA - TOC的生理性摄取。
