Arcia Franchini Ana P, Iskander Beshoy, Anwer Fatima, Oliveri Federico, Fotios Kakargias, Panday Priyanka, Hamid Pousette
Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, Bon Secours Mercy Health - St. Elizabeth Youngstown Hospital (NEOMED), Ohio, USA.
Cureus. 2022 Jan 17;14(1):e21331. doi: 10.7759/cureus.21331. eCollection 2022 Jan.
Chlamydia trachomatis (CT) is an obligate intracellular, Gram-negative bacterium that causes a variety of infections in both humans and animals. It is the causative agent of one of the most common sexually transmitted infections (STIs) with sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility. Furthermore, Chlamydia infections have been epidemiologically linked to cervical cancer (CC) in patients with human papillomavirus (HPV) coinfection. However, a molecular mechanism linking Chlamydia to CC is yet to be established, and we still do not know if more aggressive diagnosis and treatment of Chlamydia could possibly lead to lower incidences of CC and associated mortality. Since CC is a leading cause of death among women worldwide, and HPV infection alone is insufficient to cause cancer, our goal was to determine the link between Chlamydia, HPV, and CC. This literature review aimed to understand the pathologic model of CC and how Chlamydia might induce or promote carcinogenesis alone or alongside HPV. In addition, we compared multiple studies attempting to associate Chlamydial infection with CC in different populations and aimed to determine whether there is an epidemiological correlation or not.
沙眼衣原体（CT）是一种专性细胞内寄生的革兰氏阴性细菌，可在人类和动物中引起多种感染。它是最常见的性传播感染（STIs）之一的病原体，可导致盆腔炎、异位妊娠和不孕等后遗症。此外，在人乳头瘤病毒（HPV）合并感染的患者中，衣原体感染在流行病学上与宫颈癌（CC）有关。然而，将衣原体与宫颈癌联系起来的分子机制尚未确立，我们也仍然不知道对衣原体进行更积极的诊断和治疗是否可能导致宫颈癌发病率和相关死亡率降低。由于宫颈癌是全球女性死亡的主要原因之一，而且仅HPV感染不足以导致癌症，我们的目标是确定衣原体、HPV和宫颈癌之间的联系。这篇文献综述旨在了解宫颈癌的病理模型，以及衣原体如何单独或与HPV一起诱导或促进癌变。此外，我们比较了多项试图将衣原体感染与不同人群的宫颈癌联系起来的研究，旨在确定是否存在流行病学关联。
