Kirikae T, Yoshida M, Sawada H, Tezuka H, Fujita J, Mori K J
Biomed Pharmacother. 1986;40(1):6-10.
Salmonella infection induces a marked increase in the splenic granulopoiesis, but causes a reduction in hemopoiesis in the bone marrow. In this study, effects of Salmonella enteritidis infection on hemopoietic stem cells were examined in splenectomized (SX-) mice. Splenectomy emphasized hemopoietic damage in the bone marrow caused by Salmonella infection. Total nucleated cells, pluripotent stem cells (CFUs) and granulocyte-macrophage progenitor cells (GM-CFC) in the bone marrow of SX-mice all decreased markedly compared with sham-splenectomized (NX-) mice, and the recovery from the decline was also delayed. Thus, neither enhancement of the granulopoiesis nor granulopoietic recovery in the bone marrow was observed to compensate the granulopoietic response in the spleen. Splenectomy also resulted in a longlasting retention of Salmonella in the liver. The observations indicate that the spleen is the major organ to respond to bacterial invasion in regard to enhanced granulopoiesis and hence enhanced bacterial clearance.
沙门氏菌感染会导致脾脏粒细胞生成显著增加，但会使骨髓造血功能降低。在本研究中，我们在脾切除（SX-）小鼠中检测了肠炎沙门氏菌感染对造血干细胞的影响。脾切除加重了沙门氏菌感染所致的骨髓造血损伤。与假脾切除（NX-）小鼠相比，SX-小鼠骨髓中的总核细胞、多能干细胞（CFUs）和粒细胞-巨噬细胞祖细胞（GM-CFC）均显著减少，且从减少状态恢复的过程也延迟了。因此，未观察到骨髓中粒细胞生成的增强或粒细胞生成的恢复来补偿脾脏中的粒细胞生成反应。脾切除还导致沙门氏菌在肝脏中长期留存。这些观察结果表明，就增强粒细胞生成从而增强细菌清除而言，脾脏是应对细菌入侵的主要器官。
