Miyanomae T, Okabe T, Mori K J, Seto A
Biomed Pharmacother. 1982;36(6-7):286-91.
Effects of Salmonella enteritidis infection on hemopoietic stem cells were examined in mice immunized with killed bacteria and in those immunized with viable bacteria. The results are summarized as follows: i) Mice immunized with the killed salmonellae showed hemopoietic responses similar to those of normal, nonimmunized mice, i. e., increase in CFUs and CFUc in the spleen and decrease in these cells in the bone marrow. ii) Mice immunized with viable salmonellae were protected from such decreases in bone marrow stem cells, but showed a decrease in spleen CFUc, with a concomitant decrease in the peripheral granulocytes. iii) Hemopoietic responses to viable salmonellae of mice immunized with viable bacteria differed from the responses to killed salmonellae of normal, non-immunized mice. These results suggest that both LPS and cell-mediated immune responses affect hemopoietic stem cells in mice infected with salmonellae.
在用灭活细菌免疫的小鼠和用活细菌免疫的小鼠中检测肠炎沙门氏菌感染对造血干细胞的影响。结果总结如下：i）用灭活沙门氏菌免疫的小鼠表现出与正常未免疫小鼠相似的造血反应，即脾脏中集落形成单位（CFUs）和集落形成细胞（CFUc）增加，而骨髓中这些细胞减少。ii）用活沙门氏菌免疫的小鼠可免受骨髓干细胞的这种减少影响，但脾脏CFUc减少，同时外周粒细胞减少。iii）用活细菌免疫的小鼠对活沙门氏菌的造血反应与正常未免疫小鼠对灭活沙门氏菌的反应不同。这些结果表明，脂多糖（LPS）和细胞介导的免疫反应均影响感染沙门氏菌的小鼠的造血干细胞。
