International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Faculty of Medicine, Public Health, and Nursing/Academic Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia.
BMC Cardiovasc Disord. 2024 Mar 12;24(1):150. doi: 10.1186/s12872-024-03817-y.
The present study aimed to investigate the predictive ability of selected adiposity indices, such as body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and waist-to-height ratio (WHtR), for new-onset hypertension in metabolically healthy Taiwanese adults. The study also sought to establish sex-specific cutoff points for these indices and to analyze the risk of new-onset hypertension, taking into account sex and age.
This prospective cohort study utilized the Taiwan Biobank database to examine metabolically healthy participants aged between 20 and 65 at baseline. Four adiposity indices, namely BMI, WHR, WC, and WHtR, were calculated and used to predict new-onset hypertension over 4 years. Receiver operating characteristics (ROCs) and areas under the curve (AUCs) were used to evaluate the effectiveness of the parameters in predicting new-onset hypertension over 4 years. Sex-specific cutoff points were identified and used to assess the risk of new-onset hypertension.
This study analyzed 13,375 participants over 4.28 years. The incidence of new-onset hypertension was 17.65%. The new-onset rate of hypertension was 34.39% in men and 65.61% in women. Adiposity indices effectively predict new-onset hypertension, with WHtR having the highest predictive value (i.e., AUC) for both sexes. The classification of participants into low and high categories for each adiposity index was based on sex-specific cutoff points, and the risk of new-onset hypertension was assessed according to sex and age. This study found that high adiposity indices predicted a significantly higher risk of new-onset hypertension in metabolically healthy adults. The risk was equal for both sexes. Young women had a higher risk of new-onset hypertension than middle-aged women when they were further categorized. All risk ratios of the indices in young women were over two-fold and significant.
According to the sex-specific cutoff point, high adiposity indices had a higher predictive value for new-onset hypertension in metabolically healthy Taiwanese young women.
本研究旨在探讨身体质量指数（BMI）、腰臀比（WHR）、腰围（WC）和腰高比（WHtR）等选定肥胖指数对新诊断高血压的预测能力。本研究还试图为这些指数建立性别特异性切点，并分析考虑性别和年龄的新诊断高血压风险。
本前瞻性队列研究利用台湾生物银行数据库，检查基线时年龄在 20 至 65 岁之间的代谢健康参与者。计算了四个肥胖指数，即 BMI、WHR、WC 和 WHtR，用于预测 4 年内新诊断的高血压。使用受试者工作特征（ROC）和曲线下面积（AUC）评估参数预测 4 年内新诊断高血压的有效性。确定性别特异性切点，用于评估新诊断高血压的风险。
本研究分析了 13375 名参与者，随访时间为 4.28 年。新诊断高血压的发生率为 17.65%。男性新诊断高血压的发生率为 34.39%，女性为 65.61%。肥胖指数可有效预测新诊断高血压，WHtR 对两性的预测价值（即 AUC）最高。根据性别特异性切点，将参与者分为低和高两类，根据性别和年龄评估新诊断高血压的风险。本研究发现，高肥胖指数预测代谢健康成年人新发高血压的风险显著增加。两性风险相同。当进一步分类时，年轻女性的新诊断高血压风险高于中年女性。所有年轻女性指数的风险比均超过两倍且有统计学意义。
根据性别特异性切点，高肥胖指数对代谢健康的台湾年轻女性新发高血压具有更高的预测价值。
