Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt.
Pathol Res Pract. 2022 Sep;237:154053. doi: 10.1016/j.prp.2022.154053. Epub 2022 Jul 29.
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have been made to improve the patient care of LC patients, as well as the development of efficient methods and a wider range of biomarkers for prognosis, diagnosis, and treatment purposes. MicroRNAs (miRs, miRNAs) regulate a wide range of cellular functions and play a key role in the development and spreading of LC by inhibiting or degrading the expression of their target protein-coding genes. Because of their dysregulation and disruption in function, miRNAs have been linked to the malignant pathophysiology of LC by influencing many cellular functions involved in the disease. These biological processes include increased invasive and proliferative potential, cell cycle abnormality, apoptosis evasion, promotion of angiogenesis, EMT and metastasis, and reduced susceptibility to certain treatments. Here, we discuss the findings from recent years that show the role of oncogenic and TS miRNAs in LC, as well as their significance in LC pathogenesis, and resistance to anticancer therapy. We also explore the biological relevance of miRNAs and their clinical application in LC diagnosis and prognosis.
肺癌（LC）是全球最常见的癌症相关死亡原因，为了改善 LC 患者的护理，以及开发用于预后、诊断和治疗目的的有效方法和更广泛的生物标志物，已经做出了许多努力。微小 RNA（miRs，miRNAs）调节广泛的细胞功能，并通过抑制或降解其靶蛋白编码基因的表达，在 LC 的发展和扩散中发挥关键作用。由于其失调和功能障碍，miRNAs 通过影响涉及疾病的许多细胞功能与 LC 的恶性病理生理学相关。这些生物过程包括增加的侵袭性和增殖潜力、细胞周期异常、细胞凋亡逃逸、促进血管生成、EMT 和转移，以及对某些治疗的敏感性降低。在这里，我们讨论了近年来的研究结果，这些结果表明致癌和 TS miRNAs 在 LC 中的作用，以及它们在 LC 发病机制和对抗癌治疗的耐药性中的意义。我们还探讨了 miRNAs 的生物学相关性及其在 LC 诊断和预后中的临床应用。
