取代芳烃对大肠杆菌黏附人上皮细胞的抑制作用。
Inhibitory effect of substituted aromatic hydrocarbons on adherence of Escherichia coli to human epithelial cells.
作者信息
Falkowski W, Edwards M, Schaeffer A J
出版信息
Infect Immun. 1986 Jun;52(3):863-6. doi: 10.1128/iai.52.3.863-866.1986.
Abstract
Adherence of Escherichia coli to epithelial cells is postulated to be a necessary step in the pathogenesis of urinary tract infections. Investigations have focused on the role of carbohydrates in adherence because of the ability of mannose to inhibit adherence; however, there have been several reports of an additional hydrophobic receptor. Here we describe the inhibition of adherence mediated by substituted aromatic hydrocarbon compounds and the relationship of our findings to support the role of a postulated hydrophobic-binding domain.
摘要
大肠杆菌对上皮细胞的黏附被认为是尿路感染发病机制中的一个必要步骤。由于甘露糖具有抑制黏附的能力，研究主要集中在碳水化合物在黏附中的作用；然而，已有几篇关于另外一种疏水受体的报道。在此，我们描述了取代芳烃化合物介导的黏附抑制作用，以及我们的研究结果之间的关系，以支持假定的疏水结合结构域的作用。
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Hemagglutination by purified type I Escherichia coli pili.纯化的I型大肠杆菌菌毛的血细胞凝集作用。
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