• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Glycoprotein glycans that inhibit adhesion of Escherichia coli mediated by K99 fimbriae: treatment of experimental colibacillosis.抑制由K99菌毛介导的大肠杆菌黏附的糖蛋白聚糖：实验性大肠杆菌病的治疗
Infect Immun. 1990 Jan;58(1):98-106. doi: 10.1128/iai.58.1.98-106.1990.
2
Pilus-mediated binding of bovine enterotoxigenic Escherichia coli to calf small intestinal mucins.菌毛介导的牛产肠毒素大肠杆菌与犊牛小肠黏蛋白的结合
Infect Immun. 1987 May;55(5):1216-23. doi: 10.1128/iai.55.5.1216-1223.1987.
3
Use of specific antibody to demonstrate glycocalyx, K99 pili, and the spatial relationships of K99+ enterotoxigenic Escherichia coli in the ileum of colostrum-fed calves.使用特异性抗体来证明初乳喂养犊牛回肠中糖萼、K99菌毛以及K99+产肠毒素大肠杆菌的空间关系。
Infect Immun. 1982 Sep;37(3):1170-80. doi: 10.1128/iai.37.3.1170-1180.1982.
4
Immunization of calves against enterotoxigenic colibacillosis by vaccinating dams with purified K99 antigen and whole cell bacterins.通过用纯化的K99抗原和全细胞菌苗给母牛接种来对犊牛进行抗产肠毒素大肠杆菌病的免疫接种。
Infect Immun. 1979 Jul;25(1):121-6. doi: 10.1128/iai.25.1.121-126.1979.
5
Enterotoxigenic Escherichia coli strains bind bovine milk gangliosides in a ceramide-dependent process.产肠毒素大肠杆菌菌株通过一种神经酰胺依赖性过程结合牛乳神经节苷脂。
Lipids. 2003 Jul;38(7):761-8. doi: 10.1007/s11745-003-1124-7.
6
A comparison of histopathological changes in calves associated with K99- and K99+ strains of enterotoxigenic Escherichia coli.与产肠毒素大肠杆菌K99 - 和K99 + 菌株相关的犊牛组织病理学变化比较
Can J Comp Med. 1983 Apr;47(2):143-9.
7
[Frequency of FY and K99 pili in strains of Escherichia coli isolated from diarrheal calves in France].[法国腹泻犊牛分离的大肠杆菌菌株中FY菌毛和K99菌毛的频率]
Ann Rech Vet. 1985;16(1):25-8.
8
Reduction of enterotoxin induced fluid accumulation in ileal loops of neonatal calves with anti-F5 fimbriae recombinant antibody.用抗F5菌毛重组抗体减少新生犊牛回肠袢中肠毒素诱导的液体蓄积。
Vet Res Commun. 2015 Dec;39(4):229-36. doi: 10.1007/s11259-015-9646-1. Epub 2015 Oct 31.
9
[Kinetics of fecal excretion of Escherichia coli K99+ by calves after experimental infection].[实验感染后犊牛粪便中大肠杆菌K99+的排泄动力学]
Ann Rech Vet. 1983;14(2):141-6.
10
Enterotoxigenic K99+ Escherichia coli attachment to host cell receptors inhibited by recombinant pili protein.重组菌毛蛋白抑制产肠毒素K99+大肠杆菌对宿主细胞受体的附着
Vet Microbiol. 2004 Jul 14;101(3):153-60. doi: 10.1016/j.vetmic.2004.03.019.

引用本文的文献

1
Sialyllactose Attenuates Inflammation and Injury of Intestinal Epithelial Cells upon Enterotoxigenic Infection.唾液乳糖减轻产肠毒素感染时肠道上皮细胞的炎症和损伤。
Int J Mol Sci. 2025 Apr 18;26(8):3860. doi: 10.3390/ijms26083860.
2
Structural Characterization and Abundance of Sialylated Milk Oligosaccharides in Holstein Cows during Early Lactation.荷斯坦奶牛泌乳早期唾液酸化乳寡糖的结构表征与丰度
Foods. 2024 Aug 7;13(16):2484. doi: 10.3390/foods13162484.
3
Animal Enterotoxigenic Escherichia coli.动物产肠毒素大肠杆菌
EcoSal Plus. 2016 Oct;7(1). doi: 10.1128/ecosalplus.ESP-0006-2016.
4
A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection.口服干酪乳杆菌疫苗的1期试验使针对传染性胃肠炎冠状病毒感染的Th2细胞免疫极化。
Appl Microbiol Biotechnol. 2016 Sep;100(17):7457-69. doi: 10.1007/s00253-016-7424-9. Epub 2016 Mar 28.
5
Inhibition of Pasteurella multocida Adhesion to Rabbit Respiratory Epithelium Using Lectins.使用凝集素抑制多杀性巴氏杆菌对兔呼吸道上皮的黏附
Vet Med Int. 2015;2015:365428. doi: 10.1155/2015/365428. Epub 2015 Feb 24.
6
The role of bacteria in the pathogenesis of inflammatory bowel disease.细菌在炎症性肠病发病机制中的作用。
Gut Liver. 2010 Sep;4(3):295-306. doi: 10.5009/gnl.2010.4.3.295. Epub 2010 Sep 24.
7
A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics.糖生物学综述：碳水化合物、凝集素及其在癌症治疗中的意义。
Acta Histochem. 2011 May;113(3):236-47. doi: 10.1016/j.acthis.2010.02.004. Epub 2010 Mar 2.
8
Treatment of calf diarrhea: antimicrobial and ancillary treatments.犊牛腹泻的治疗：抗菌及辅助治疗。
Vet Clin North Am Food Anim Pract. 2009 Mar;25(1):101-20, vi. doi: 10.1016/j.cvfa.2008.10.012.
9
Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro.在体外，乳酸菌菌株黏附于肠上皮细胞后会分泌细胞外MUC3黏蛋白。
Gut. 2003 Jun;52(6):827-33. doi: 10.1136/gut.52.6.827.
10
Characterization of FasG segments required for 987P fimbria-mediated binding to piglet glycoprotein receptors.987P菌毛介导与仔猪糖蛋白受体结合所需的FasG片段的特性分析。
Infect Immun. 2001 Nov;69(11):6625-32. doi: 10.1128/IAI.69.11.6625-6632.2001.

本文引用的文献

1
Antibiotic resistance in veterinary practice.兽医实践中的抗生素耐药性。
In Pract. 1982 Jan;4(1):11-5. doi: 10.1136/inpract.4.1.11.
2
Purification, characterization, and partial covalent structure of Escherichia coli adhesive antigen K99.大肠杆菌黏附性抗原K99的纯化、特性鉴定及部分共价结构
Infect Immun. 1981 Sep;33(3):877-83. doi: 10.1128/iai.33.3.877-883.1981.
3
Nonimmunoglobulin fraction of human milk inhibits bacterial adhesion (hemagglutination) and enterotoxin binding of Escherichia coli and Vibrio cholerae.人乳的非免疫球蛋白部分可抑制大肠杆菌和霍乱弧菌的细菌黏附（血细胞凝集）及肠毒素结合。
Infect Immun. 1981 Jul;33(1):136-41. doi: 10.1128/iai.33.1.136-141.1981.
4
Inhibition of enterotoxin from Escherichia coli and Vibrio cholerae by gangliosides from human milk.人乳神经节苷脂对大肠杆菌和霍乱弧菌肠毒素的抑制作用。
Infect Immun. 1983 May;40(2):563-9. doi: 10.1128/iai.40.2.563-569.1983.
5
Receptor-like glycocompounds in human milk that inhibit classical and El Tor Vibrio cholerae cell adherence (hemagglutination).人乳中可抑制典型霍乱弧菌和埃尔托霍乱弧菌细胞黏附（血细胞凝集）的类受体糖化合物。
Infect Immun. 1983 Jan;39(1):147-54. doi: 10.1128/iai.39.1.147-154.1983.
6
Isolation and structural characterization of the equine erythrocyte receptor for enterotoxigenic Escherichia coli K99 fimbrial adhesin.产肠毒素大肠杆菌K99菌毛黏附素的马红细胞受体的分离与结构表征
Infect Immun. 1984 Nov;46(2):578-84. doi: 10.1128/iai.46.2.578-584.1984.
7
K99 surface haemagglutinin of enterotoxigenic E. coli recognize terminal N-acetylgalactosamine and sialic acid residues of glycophorin and other complex glycoconjugates.产肠毒素大肠杆菌的K99表面血凝素可识别血型糖蛋白及其他复合糖缀合物的末端N-乙酰半乳糖胺和唾液酸残基。
Vet Microbiol. 1984 Jul;9(3):249-57. doi: 10.1016/0378-1135(84)90042-7.
8
Production, purification, and characterization of the fimbrial adhesive antigen F41 isolated from calf enteropathogenic Escherichia coli strain B41M.从犊牛肠道致病性大肠杆菌B41M菌株中分离的菌毛粘附抗原F41的制备、纯化及特性分析
Infect Immun. 1982 May;36(2):751-8. doi: 10.1128/iai.36.2.751-758.1982.
9
Binding of intraluminal toxin in cholera: trial of GM1 ganglioside charcoal.霍乱中肠腔内毒素的结合：GM1神经节苷脂炭试验
Lancet. 1980 Oct 25;2(8200):888-91. doi: 10.1016/s0140-6736(80)92049-8.
10
[Culture of calf intestinal tissue. Study of cell differentiation and disaccharase activities].[小牛肠道组织培养。细胞分化及双糖酶活性研究]
C R Acad Hebd Seances Acad Sci D. 1967 Jan 16;264(3):519-21.

抑制由K99菌毛介导的大肠杆菌黏附的糖蛋白聚糖：实验性大肠杆菌病的治疗

Glycoprotein glycans that inhibit adhesion of Escherichia coli mediated by K99 fimbriae: treatment of experimental colibacillosis.

作者信息

Mouricout M, Petit J M, Carias J R, Julien R

机构信息

Faculté des Sciences, Université de Limoges, France.

出版信息

Infect Immun. 1990 Jan;58(1):98-106. doi: 10.1128/iai.58.1.98-106.1990.

DOI:10.1128/iai.58.1.98-106.1990
PMID:2403535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258414/
Abstract

Calf diarrhea due to infection by enterotoxigenic Escherichia coli was treated by administration of glycoprotein glycans derived from bovine plasma. The glycan moieties of the nonimmunoglobulin fraction of plasma mimicked the oligosaccharide moiety of intestinal receptors recognized by K99 pili. These glycoprotein glycans inhibited adhesion of E. coli K99+ ST+ to erythrocyte glycoconjugates in vitro, and they protected colostrum-deprived newborn calves against lethal doses of enterotoxigenic E. coli (10(10) bacteria). Adhesion of bacteria to the intestines (duodenum, jejunum, and ileum) was significantly reduced (by 2 orders of magnitude) in treated calves.

摘要

由产肠毒素大肠杆菌感染引起的犊牛腹泻，通过给予源自牛血浆的糖蛋白聚糖进行治疗。血浆中非免疫球蛋白部分的聚糖部分模拟了被K99菌毛识别的肠道受体的寡糖部分。这些糖蛋白聚糖在体外抑制大肠杆菌K99 + ST +与红细胞糖缀合物的粘附，并且它们保护初乳缺乏的新生犊牛免受致死剂量的产肠毒素大肠杆菌（10¹⁰个细菌）的侵害。在接受治疗的犊牛中，细菌对肠道（十二指肠、空肠和回肠）的粘附显著减少（降低了2个数量级）。