抑制由K99菌毛介导的大肠杆菌黏附的糖蛋白聚糖：实验性大肠杆菌病的治疗
Glycoprotein glycans that inhibit adhesion of Escherichia coli mediated by K99 fimbriae: treatment of experimental colibacillosis.
作者信息
Mouricout M, Petit J M, Carias J R, Julien R
机构信息
Faculté des Sciences, Université de Limoges, France.
出版信息
Infect Immun. 1990 Jan;58(1):98-106. doi: 10.1128/iai.58.1.98-106.1990.
Abstract
Calf diarrhea due to infection by enterotoxigenic Escherichia coli was treated by administration of glycoprotein glycans derived from bovine plasma. The glycan moieties of the nonimmunoglobulin fraction of plasma mimicked the oligosaccharide moiety of intestinal receptors recognized by K99 pili. These glycoprotein glycans inhibited adhesion of E. coli K99+ ST+ to erythrocyte glycoconjugates in vitro, and they protected colostrum-deprived newborn calves against lethal doses of enterotoxigenic E. coli (10(10) bacteria). Adhesion of bacteria to the intestines (duodenum, jejunum, and ileum) was significantly reduced (by 2 orders of magnitude) in treated calves.
摘要
由产肠毒素大肠杆菌感染引起的犊牛腹泻，通过给予源自牛血浆的糖蛋白聚糖进行治疗。血浆中非免疫球蛋白部分的聚糖部分模拟了被K99菌毛识别的肠道受体的寡糖部分。这些糖蛋白聚糖在体外抑制大肠杆菌K99 + ST +与红细胞糖缀合物的粘附，并且它们保护初乳缺乏的新生犊牛免受致死剂量的产肠毒素大肠杆菌（10¹⁰个细菌）的侵害。在接受治疗的犊牛中，细菌对肠道（十二指肠、空肠和回肠）的粘附显著减少（降低了2个数量级）。
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