光可逆嘧啶二聚体在紫外线诱导切除缺陷型大肠杆菌原养型突变中的新作用。
New role for photoreversible pyrimidine dimers in induction of prototrophic mutations in excision-deficient Escherichia coli by UV light.
作者信息
Ruiz-Rubio M, Woodgate R, Bridges B A, Herrera G, Blanco M
出版信息
J Bacteriol. 1986 Jun;166(3):1141-3. doi: 10.1128/jb.166.3.1141-1143.1986.
Abstract
UV mutagenesis to His+ in certain recA441 lexA51 bacteria was not photoreversible, indicating that pyrimidine dimers are not target lesions. Photoreversibility was observed in recA+ lexA51 bacteria, showing that pyrimidine dimers are needed to activate the recA+ protein (unlike the recA441 protein) to perform a function in UV mutagenesis distinct from cleavage of the lexA repressor.
摘要
在某些recA441 lexA51细菌中，紫外线诱变产生His+的过程不可光逆转，这表明嘧啶二聚体不是目标损伤。在recA+ lexA51细菌中观察到了光逆转现象，这表明嘧啶二聚体是激活recA+蛋白（与recA441蛋白不同）以在紫外线诱变中发挥不同于裂解lexA阻遏物的功能所必需的。
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