Département de Chimie, Université de Constantine 1, Constantine, 25000, Algeria.
Département de Chimie, Université de 20 Aout 1955, Skikda, 21000, Algeria.
J Nat Prod. 2022 Mar 25;85(3):647-656. doi: 10.1021/acs.jnatprod.1c01211. Epub 2022 Feb 23.
Seven new terpenoids, namely, guaiane (-), eudesmane (), and bisabolane () sesquiterpenoids and a furanone (), were isolated from the aerial parts of , a herbaceous plant growing in Algeria, together with eight known compounds. All metabolites were characterized by their 1D and 2D NMR and HRESIMS data. A combined DFT/NMR method was applied to study the relative configurations of -, , and . All compounds, except , were assayed against MCF-7, A375, A549, HaCaT, and Jurkat cell lines. Compounds , , and induced a dose-dependent reduction in cell viability with different potency on almost all cell lines used. The most active compounds, and , were studied to assess their potential apoptotic effects and cell cycle inhibition.
从生长在阿尔及利亚的草本植物中分离得到了七种新的萜类化合物，即 (-) 愈创木烷型、 () 艾里莫芬烷型和 () 倍半萜烯和一种呋喃酮 ()，以及八种已知化合物。所有代谢物均通过 1D 和 2D NMR 和 HRESIMS 数据进行了表征。应用组合 DFT/NMR 方法研究了 -、- 和 - 的相对构型。除了 - 之外，所有化合物均针对 MCF-7、A375、A549、HaCaT 和 Jurkat 细胞系进行了测试。化合物 -、- 和 - 诱导细胞活力呈剂量依赖性降低，对几乎所有使用的细胞系均具有不同的活性。对最活性的化合物 - 和 - 进行了研究，以评估它们潜在的凋亡作用和细胞周期抑制作用。
