School of Medicine, Tehran University of Medical Sciences (TUMS), Children's Medical Center Hospital, Dr. Qarib St., Keshavarz Blvd, 14194, Tehran, Iran.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Mol Brain. 2022 Feb 23;15(1):20. doi: 10.1186/s13041-022-00905-y.
Alzheimer's disease (AD), a critical neurodegenerative condition, has a wide range of effects on brain activity. Synaptic plasticity and neuronal circuits are the most vulnerable in Alzheimer's disease, but the exact mechanism is unknown. Incorporating optogenetics into the study of AD has resulted in a significant leap in this field during the last decades, kicking off a revolution in our knowledge of the networks that underpin cognitive functions. In Alzheimer's disease, optogenetics can help to reduce and reverse neural circuit and memory impairments. Here we review how optogenetically driven methods have helped expand our knowledge of Alzheimer's disease, and how optogenetic interventions hint at a future translation into therapeutic possibilities for further utilization in clinical settings. In conclusion, neuroscience has witnessed one of its largest revolutions following the introduction of optogenetics into the field.
阿尔茨海默病（AD）是一种严重的神经退行性疾病，对大脑活动有广泛的影响。在阿尔茨海默病中，突触可塑性和神经元回路最容易受到影响，但确切的机制尚不清楚。将光遗传学纳入 AD 的研究在过去几十年中取得了重大进展，引发了我们对认知功能基础网络的认识的革命。在阿尔茨海默病中，光遗传学可以帮助减少和逆转神经回路和记忆损伤。在这里，我们回顾了光遗传学驱动的方法如何帮助我们扩大对阿尔茨海默病的认识，以及光遗传学干预如何暗示未来在临床环境中进一步利用治疗的可能性。总之，神经科学见证了其最大的革命之一，即光遗传学引入该领域。
