Wang Liusheng, Ke Jingqi, Zhang Haiyan
Teachers College, Jimei University, Xiamen, China.
Institute of Special Environment Medicine, Nantong University, Nantong, China.
Front Hum Neurosci. 2022 Feb 7;16:760738. doi: 10.3389/fnhum.2022.760738. eCollection 2022.
The present study aimed to examine the neural mechanisms underlying the ability to process the mental rotation with mirrored stimuli for different depressive tendencies with psychomotor retardation. Using functional near-infrared spectroscopy (fNIRS), we measured brain cortex activation of participants with higher and lower depressive tendencies while performing a left-right paradigm of object mental rotation or a same-different paradigm of subject mental rotation. Behavioral data revealed no differences in reaction time and rotation speed. The fNIRS data revealed a higher deactivation of oxyhemoglobin (HbO) change for the higher depression group in the perceptual stage of object mental rotation with mirrored stimuli in the superior external frontal cortex (BA46), inferior frontal gyrus (BA45), premotor cortex (BA6), and primary motor cortex (BA4) (study 1). In addition, there existed a significant difference between the two groups in premotor cortex (BA6) in subject mental rotation with mirrored stimuli (study 2). These results suggest that the neural mechanism of higher depression individuals connected with psychomotor retardation exists in the frontal and motor areas when processing object mental rotation with mirrored stimuli, and the motor cortex when processing subject mental rotation.
本研究旨在探讨不同抑郁倾向伴精神运动迟缓者处理镜像刺激心理旋转能力背后的神经机制。我们使用功能近红外光谱技术（fNIRS），在参与者进行物体心理旋转的左右范式或主体心理旋转的异同范式时，测量了抑郁倾向较高和较低者的大脑皮层激活情况。行为数据显示反应时间和旋转速度没有差异。fNIRS数据显示，在物体心理旋转的感知阶段，对于抑郁程度较高的组，在额上回外侧（BA46）、额下回（BA45）、运动前区皮层（BA6）和初级运动皮层（BA4）中，镜像刺激下的氧合血红蛋白（HbO）变化去激活程度更高（研究1）。此外，在主体心理旋转的镜像刺激中，两组在运动前区皮层（BA6）存在显著差异（研究2）。这些结果表明，在处理镜像刺激的物体心理旋转时，与精神运动迟缓相关的高抑郁个体的神经机制存在于额叶和运动区域，而在处理主体心理旋转时存在于运动皮层。
