Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis 15771, Athens, Greece.
Chempluschem. 2022 Apr;87(4):e202200008. doi: 10.1002/cplu.202200008. Epub 2022 Feb 23.
Sulfoxides constitute one of the most important functional groups in organic chemistry found in numerous pharmaceuticals and natural products. Sulfoxides are usually obtained from the oxidation of the corresponding sulfides. Among various oxidants, oxygen or air are considered the greenest and most sustainable reagent. Photochemistry and photocatalysis is increasingly applied in new, as well as traditional, yet demanding, reaction, like the aerobic oxidation of sulfides to sulfoxides, since photocatalysis has provided the means to access them in mild and effective ways. In this review, we will summarize the photochemical protocols that have been developed for the oxidation of sulfides to sulfoxides, employing air or oxygen as the oxidant. The aim of this review is to present: i) a historical overview, ii) the key mechanistic studies and proposed mechanisms and iii) categorize the different catalytic systems in literature.
亚砜是有机化学中最重要的官能团之一，存在于许多药物和天然产物中。亚砜通常是通过相应的硫化物氧化得到的。在各种氧化剂中，氧气或空气被认为是最环保和最可持续的试剂。光化学和光催化越来越多地应用于新的、传统的但要求苛刻的反应，如硫化物的有氧氧化为亚砜，因为光催化提供了以温和有效的方式获得它们的手段。在这篇综述中，我们将总结发展的用于亚砜氧化为亚砜的光化学方法，使用空气或氧气作为氧化剂。本文综述的目的是：i）介绍历史概况，ii）关键的机理研究和提出的机理，iii）对文献中的不同催化体系进行分类。
