Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Department of Internal Medicine, Bronx Lebanon Hospital, USA.
JNMA J Nepal Med Assoc. 2022 Jan 15;60(245):86-89. doi: 10.31729/jnma.7118.
Stevens-Johnson syndrome and toxic epidermal necrolysis represent a spectrum of severe mucocutaneous reactions, while Acute Cutaneous Lupus Erythematosus is a variant of Systemic Lupus Erythematosus. Both are rare conditions, with significant morbidity and mortality; often indistinguishable clinically and pose a diagnostic dilemma for the clinician. We hereby present a unique case of a 17 years old female who presented with widespread vesiculobullous lesions with peeling, desquamation, and crusting of the skin surface, non-scarring alopecia, oral and nasal ulcers, as well as two episodes of generalized tonic-clonic seizures. The patient had a history of intake of itraconazole tablets for a week, 25 days before the disease manifestation.
史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症代表了一组严重的黏膜皮肤反应，而急性皮肤狼疮红斑则是系统性红斑狼疮的一种变异。这两种疾病都很罕见，但发病率和死亡率很高；临床上往往难以区分，给临床医生带来诊断难题。我们在此介绍一例 17 岁女性患者，她表现为广泛的水疱性大疱性病变，伴有皮肤表面剥脱、脱皮和结痂，非瘢痕性脱发，口腔和鼻腔溃疡，以及两次全身性强直-阵挛性发作。该患者在疾病发作前 25 天曾因服用伊曲康唑片一周。
