Department of Dermatology, University of Sao Paulo, Brazil.
Acta Derm Venereol. 2010 Mar;90(2):175-8. doi: 10.2340/00015555-0785.
Toxic epidermal necrolysis-like lesions have been described in the setting of lupus erythematosus, and have been considered as a specific hyperacute variant of cutaneous lupus erythematosus, with features different from classical drug-related toxic epidermal necrolysis. We report here a series of three patients with lupus erythematosus who presented with severe worsening of their cutaneous disease in a toxic epidermal necrolysis-like fashion. We compared these cases with cases reported previously. Based on this discussion, we speculate that some of these patients may have classical drug-related toxic epidermal necrolysis rather than lupus erythematosus-related toxic epidermal necrolysis.
中毒性表皮坏死松解样病变已在红斑狼疮的情况下被描述，并且被认为是皮肤红斑狼疮的一种特定的超急性变异型，其特征与经典的药物相关的中毒性表皮坏死松解不同。我们在此报告三例红斑狼疮患者，其皮肤疾病以中毒性表皮坏死松解样方式严重恶化。我们将这些病例与以前报告的病例进行了比较。基于此讨论，我们推测其中一些患者可能患有经典的药物相关的中毒性表皮坏死松解，而不是红斑狼疮相关的中毒性表皮坏死松解。
