Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Department of Neurology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2021 Sep 11;59(241):922-924. doi: 10.31729/jnma.6644.
Metronidazole is a widely used antibiotic against bacterial and protozoan infections. Even though the therapeutic use of the drug is high, it is associated with some severe side effects like neurotoxicity such as optic neuropathy, peripheral neuropathy, encephalopathy and cerebellar toxicity. We present a case of a 55-years male presented with dysarthria, who had positive cerebellar sign and magnetic resonance imaging findings suggestive of metronidazole induced cerebellar toxicity following metronidazole therapy for two months in a case of liver abscess. And, the symptoms resolved after cessation of metronidazole.
甲硝唑是一种广泛用于治疗细菌和原生动物感染的抗生素。尽管该药物的治疗用途很高,但它与一些严重的副作用有关,如神经毒性,如视神经病变、周围神经病、脑病和小脑毒性。我们报告了一例 55 岁男性,表现为构音障碍,有小脑体征阳性,磁共振成像结果提示甲硝唑治疗肝脓肿两个月后发生甲硝唑诱导的小脑毒性。并且,停用甲硝唑后症状得到缓解。