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仙人掌涂层细菌纤维素水凝胶的制备、表征及生物学特性

Preparation, Characterization, and Biological Features of Cactus Coated Bacterial Cellulose Hydrogels.

作者信息

Kamal Tahseen, Ul-Islam Mazhar, Khan Sher Bahadar, Bakhsh Esraa M, Chani Muhammad Tariq Saeed

机构信息

Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Department of Chemical Engineering, College of Engineering, Dhofar University, Salalah 211, Oman.

出版信息

Gels. 2022 Jan 30;8(2):88. doi: 10.3390/gels8020088.

Abstract

The current study was aimed at developing BC-Cactus (BCC) composite hydrogels with impressive mechanical features for their potential applications in medical and environmental sectors. BCC composites hydrogels were developed through cactus gel coating on a never dried BC matrix. The FE-SEM micrographs confirmed the saturation of BC fibrils with cactus gel. Additionally, the presence of various functional groups and alteration in crystalline behavior was confirmed through FTIR and XRD analysis. Mechanical testing illustrated a three-times increase in the strain failure and an increase of 1.6 times in the tensile strength of BCC composite. Absorption capabilities of BCC were much higher than pure BC and it retained water for a longer period of time. Additionally, the rewetting and absorption potentials of composites were also higher than pure BC. The composite efficiently adsorbed Pb, Zn, Cu, and Co metals. Biocompatibility studies against human HaCat cell line indicated much better cell adhesion and proliferation of BCC compared to BC. These findings advocate that the BCC composite could find applications in medical, pharmaceutical and environmental fields.

摘要

当前的研究旨在开发具有令人印象深刻机械特性的细菌纤维素-仙人掌(BCC)复合水凝胶,以探索其在医学和环境领域的潜在应用。BCC复合水凝胶是通过在未干燥的细菌纤维素基质上涂覆仙人掌凝胶而制备的。场发射扫描电子显微镜(FE-SEM)显微照片证实了细菌纤维素原纤维被仙人掌凝胶饱和。此外,通过傅里叶变换红外光谱(FTIR)和X射线衍射(XRD)分析证实了各种官能团的存在以及结晶行为的变化。力学测试表明,BCC复合材料的应变破坏增加了两倍,拉伸强度增加了1.6倍。BCC的吸附能力远高于纯细菌纤维素,并且能更长时间地保持水分。此外,复合材料的再润湿和吸附潜力也高于纯细菌纤维素。该复合材料能有效吸附铅、锌、铜和钴金属。针对人HaCat细胞系的生物相容性研究表明,与细菌纤维素相比,BCC具有更好的细胞黏附性和增殖能力。这些研究结果表明,BCC复合材料可在医学、制药和环境领域得到应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3c7/8871450/4625684857c1/gels-08-00088-g001.jpg

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