Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, PR China; Department of Agricultural and Biological Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Department of Agricultural and Biological Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Carbohydr Polym. 2021 Jan 15;252:117123. doi: 10.1016/j.carbpol.2020.117123. Epub 2020 Sep 28.
Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young's modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.
细菌纤维素（BC）因其精细的 3-D 网络结构、高机械强度和保水能力以及良好的生物相容性而成为一种理想的伤口敷料材料。在这项研究中，使用 1,4-丁二醇二缩水甘油醚（BDDE）交联 BC 和透明质酸（HA）制备了一种复合水凝胶。交联后的 BC/HA 复合材料具有更致密和更光滑的表面。这种致密的形态提高了保水能力和尺寸稳定性。与未交联的 BC/HA 相比，含有 2%HA 和 1%BDDE 的 BDDE 交联的 BC/HA 复合材料具有更好的整体性能，包括水稳定性（水溶性：12.7%）、机械性能（拉伸强度：0.61MPa 和杨氏模量：1.62MPa）和热稳定性（最大降解温度：360°C）。此外，细胞毒性试验和形态学表明，BDDE 交联的 BC/HA 复合材料显著促进了细胞的增殖和黏附。这种化学交联的 BC/HA 复合材料在伤口护理方面可能有许多新的生物医学应用。
